Atenolol
Generic name: atenolol · Brand names: Tenormin
Quick facts
Drug class
Value
beta-Adrenergic Blocker [EPC]
Source
openFDA label endpoint, count of openfda.pharm_class_epc.exact for generic name ATENOLOL
Url
https://api.fda.gov/drug/label.json?search=openfda.generic_name.exact:"ATENOLOL"&count=openfda.pharm_class_epc.exact
Label wording
Atenolol is a beta1-selective (cardioselective) beta-adrenergic receptor blocking agent (Clinical Pharmacology)
Rx or otc
Rx (label principal display panel: 'Rx only'; DailyMed Product Type HUMAN PRESCRIPTION DRUG)
Forms and strengths
- Atenolol tablets are available as 25 mg, 50 mg and 100 mg tablets for oral administration. (Description)
- 25 mg: white to off-white, round, unscored, debossed A2 on one side and M on the other
- 50 mg: white, round, scored, debossed 231 above the score on one side and M on the other
- 100 mg: white, round, unscored, debossed M on one side and 757 on the other (How Supplied)
Generic available
Value
Yes: this record is the generic label (ANDA073457, Mylan)
Source
DailyMed Marketing Information, https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=a7048c81-6769-436b-8397-fbaa7489fcdf&type=display
Common use one line
Treats high blood pressure and angina, and is used in the management of acute heart attack (Indications and Usage).
What it is used for
Atenolol lowers blood pressure, helps manage long-term chest pain from coronary artery disease (angina), and is used in stable patients who are having or may be having a heart attack to lower the risk of death from heart problems.
Section
INDICATIONS AND USAGE
Source
DailyMed label, Mylan Pharmaceuticals Inc. atenolol tablets, set ID a7048c81-6769-436b-8397-fbaa7489fcdf
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=a7048c81-6769-436b-8397-fbaa7489fcdf&type=display
Source text (exact source wording)
Hypertension
Atenolol tablets are indicated for the treatment of hypertension, to lower blood pressure.
Angina Pectoris Due to Coronary Atherosclerosis
Atenolol tablets are indicated for the long-term management of patients with angina pectoris.
Acute Myocardial Infarction
Atenolol tablets are indicated in the management of hemodynamically stable patients with definite or suspected acute myocardial infarction to reduce cardiovascular mortality.
Atenolol tablets are indicated for the treatment of hypertension, to lower blood pressure.
Angina Pectoris Due to Coronary Atherosclerosis
Atenolol tablets are indicated for the long-term management of patients with angina pectoris.
Acute Myocardial Infarction
Atenolol tablets are indicated in the management of hemodynamically stable patients with definite or suspected acute myocardial infarction to reduce cardiovascular mortality.
How it works
Atenolol blocks beta1 receptors, mostly in the heart. At higher doses it can also block beta2 receptors in the lungs and blood vessels. The label says how beta-blockers lower blood pressure has not been established.
Section
CLINICAL PHARMACOLOGY
Source
DailyMed label, Mylan Pharmaceuticals Inc. atenolol tablets, set ID a7048c81-6769-436b-8397-fbaa7489fcdf
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=a7048c81-6769-436b-8397-fbaa7489fcdf&type=display
Source text (exact source wording)
Atenolol is a beta1-selective (cardioselective) beta-adrenergic receptor blocking agent without membrane stabilizing or intrinsic sympathomimetic (partial agonist) activities. This preferential effect is not absolute, however, and at higher doses, atenolol tablets inhibit beta2-adrenoreceptors, chiefly located in the bronchial and vascular musculature. The mechanisms of the antihypertensive effects of beta-blocking agents have not been established.
Dosage: adults
Hypertension
For high blood pressure the starting dose is 50 mg once a day. If needed it can go up to 100 mg once a day. Going above 100 mg a day is unlikely to help more.
Section
DOSAGE AND ADMINISTRATION
Source
DailyMed label, Mylan Pharmaceuticals Inc. atenolol tablets, set ID a7048c81-6769-436b-8397-fbaa7489fcdf
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=a7048c81-6769-436b-8397-fbaa7489fcdf&type=display
Source text (exact source wording)
Hypertension
The initial dose of atenolol is 50 mg given as one tablet a day either alone or added to diuretic therapy. The full effect of this dose will usually be seen within one to two weeks. If an optimal response is not achieved, the dosage should be increased to atenolol 100 mg given as one tablet a day. Increasing the dosage beyond 100 mg a day is unlikely to produce any further benefit.
The initial dose of atenolol is 50 mg given as one tablet a day either alone or added to diuretic therapy. The full effect of this dose will usually be seen within one to two weeks. If an optimal response is not achieved, the dosage should be increased to atenolol 100 mg given as one tablet a day. Increasing the dosage beyond 100 mg a day is unlikely to produce any further benefit.
Angina
For angina the starting dose is 50 mg once a day, raised to 100 mg if needed after one week. Some people may need 200 mg once a day.
Section
DOSAGE AND ADMINISTRATION
Source
DailyMed label, Mylan Pharmaceuticals Inc. atenolol tablets, set ID a7048c81-6769-436b-8397-fbaa7489fcdf
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=a7048c81-6769-436b-8397-fbaa7489fcdf&type=display
Source text (exact source wording)
Angina Pectoris
The initial dose of atenolol is 50 mg given as one tablet a day. If an optimal response is not achieved within one week, the dosage should be increased to atenolol 100 mg given as one tablet a day. Some patients may require a dosage of 200 mg once a day for optimal effect.
The initial dose of atenolol is 50 mg given as one tablet a day. If an optimal response is not achieved within one week, the dosage should be increased to atenolol 100 mg given as one tablet a day. Some patients may require a dosage of 200 mg once a day for optimal effect.
Acute mi
After a heart attack, tablets follow the intravenous dose given in the hospital: 50 mg, then 50 mg 12 hours later, then 100 mg once daily or 50 mg twice a day for a further 6 to 9 days or until discharge. The medicine is stopped if a slow heartbeat or low blood pressure needing treatment occurs.
Section
DOSAGE AND ADMINISTRATION
Source
DailyMed label, Mylan Pharmaceuticals Inc. atenolol tablets, set ID a7048c81-6769-436b-8397-fbaa7489fcdf
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=a7048c81-6769-436b-8397-fbaa7489fcdf&type=display
Source text (exact source wording)
Acute Myocardial Infarction
In patients who tolerate the full intravenous dose (10 mg), atenolol tablets 50 mg should be initiated 10 minutes after the last intravenous dose followed by another 50 mg oral dose 12 hours later. Thereafter, atenolol tablets can be given orally either 100 mg once daily or 50 mg twice a day for a further 6 to 9 days or until discharge from the hospital. If bradycardia or hypotension requiring treatment or any other untoward effects occur, atenolol tablets should be discontinued.
In patients who tolerate the full intravenous dose (10 mg), atenolol tablets 50 mg should be initiated 10 minutes after the last intravenous dose followed by another 50 mg oral dose 12 hours later. Thereafter, atenolol tablets can be given orally either 100 mg once daily or 50 mg twice a day for a further 6 to 9 days or until discharge from the hospital. If bradycardia or hypotension requiring treatment or any other untoward effects occur, atenolol tablets should be discontinued.
Dosage: children
The label says safety and effectiveness in children have not been established. No pediatric dose is given.
Section
PRECAUTIONS, Pediatric Use
Source
DailyMed label, Mylan Pharmaceuticals Inc. atenolol tablets, set ID a7048c81-6769-436b-8397-fbaa7489fcdf
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=a7048c81-6769-436b-8397-fbaa7489fcdf&type=display
Source text (exact source wording)
Safety and effectiveness in pediatric patients have not been established.
Dosage adjustments
Drug interaction caps
Note
No interaction-based dose cap found in the label sections read.
Kidney
Atenolol is cleared by the kidneys. When kidney function is lower (creatinine clearance 15-35 mL/min/1.73m2) the most the label allows is 50 mg daily. Below 15 mL/min/1.73m2 the most is 25 mg daily. People on hemodialysis get 25 mg or 50 mg after each dialysis, under hospital supervision.
Section
DOSAGE AND ADMINISTRATION, Elderly Patients or Patients with Renal Impairment
Source
DailyMed label, Mylan Pharmaceuticals Inc. atenolol tablets, set ID a7048c81-6769-436b-8397-fbaa7489fcdf
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=a7048c81-6769-436b-8397-fbaa7489fcdf&type=display
Source text (exact source wording)
Atenolol tablets are excreted by the kidneys; consequently dosage should be adjusted in cases of severe impairment of renal function. No significant accumulation of atenolol tablets occur until creatinine clearance falls below 35 mL/min/1.73 m2. The following maximum oral dosages are recommended for elderly, renally-impaired patients and for patients with renal impairment due to other causes:
Creatinine Clearance (mL/min/1.73m2) 15-35: Elimination Half-Life (h) 16-27: Maximum Dosage 50 mg daily
Creatinine Clearance (mL/min/1.73m2) < 15: Elimination Half-Life (h) > 27: Maximum Dosage 25 mg daily
Patients on hemodialysis should be given 25 mg or 50 mg after each dialysis; this should be done under hospital supervision as marked falls in blood pressure can occur.
Creatinine Clearance (mL/min/1.73m2) 15-35: Elimination Half-Life (h) 16-27: Maximum Dosage 50 mg daily
Creatinine Clearance (mL/min/1.73m2) < 15: Elimination Half-Life (h) > 27: Maximum Dosage 25 mg daily
Patients on hemodialysis should be given 25 mg or 50 mg after each dialysis; this should be done under hospital supervision as marked falls in blood pressure can occur.
Liver
Note
The label gives no liver-specific dose adjustment in the sections read.
Elderly
For older adults the label says to be cautious and usually start at the low end of the dose range. Some older patients treated for high blood pressure may start at 25 mg once a day.
Section
DOSAGE AND ADMINISTRATION, Elderly Patients or Patients with Renal Impairment
Source
DailyMed label, Mylan Pharmaceuticals Inc. atenolol tablets, set ID a7048c81-6769-436b-8397-fbaa7489fcdf
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=a7048c81-6769-436b-8397-fbaa7489fcdf&type=display
Source text (exact source wording)
In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy. Evaluation of patients with hypertension or myocardial infarction should always include assessment of renal function. Atenolol excretion would be expected to decrease with advancing age. Some renally-impaired or elderly patients being treated for hypertension may require a lower starting dose of atenolol tablets: 25 mg given as one tablet a day.
Missed dose
Label
Note
The Mylan label has no missed-dose instruction.
Medlineplus
Take it when you remember. If it is almost time for the next dose, skip the missed one. Do not take two doses at once.
Section
What should I do if I forget a dose?
Source
MedlinePlus
Source url
https://medlineplus.gov/druginfo/meds/a684031.html
Source text (exact source wording)
Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Overdose
People have survived a single dose as high as 5 g. One death was reported in a man who may have taken as much as 10 g. Main signs are lethargy, trouble with breathing control, wheezing, pauses in the heartbeat and a slow heartbeat. Heart failure, low blood pressure, airway tightening and low blood sugar may also occur. In case of overdose call poison control at 1-800-222-1222 (MedlinePlus).
Section
OVERDOSAGE
Source
DailyMed label, Mylan Pharmaceuticals Inc. atenolol tablets, set ID a7048c81-6769-436b-8397-fbaa7489fcdf
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=a7048c81-6769-436b-8397-fbaa7489fcdf&type=display
Poison control
Source
MedlinePlus
Source url
https://medlineplus.gov/druginfo/meds/a684031.html
Source text (exact source wording)
In case of overdose, call the poison control helpline at 1-800-222-1222.
Source text (exact source wording)
Overdosage with atenolol tablets has been reported with patients surviving acute doses as high as 5 g. One death was reported in a man who may have taken as much as 10 g acutely.
The predominant symptoms reported following atenolol tablets overdose are lethargy, disorder of respiratory drive, wheezing, sinus pause and bradycardia. Additionally, common effects associated with overdosage of any beta-adrenergic blocking agent and which might also be expected in atenolol tablets overdose are congestive heart failure, hypotension, bronchospasm and/or hypoglycemia.
The predominant symptoms reported following atenolol tablets overdose are lethargy, disorder of respiratory drive, wheezing, sinus pause and bradycardia. Additionally, common effects associated with overdosage of any beta-adrenergic blocking agent and which might also be expected in atenolol tablets overdose are congestive heart failure, hypotension, bronchospasm and/or hypoglycemia.
Storage
Store at 20° to 25°C (68° to 77°F). Pharmacies dispense it in a tight, light-resistant container. Details are for the Mylan label; other labelers may differ.
Section
HOW SUPPLIED
Source
DailyMed label, Mylan Pharmaceuticals Inc. atenolol tablets, set ID a7048c81-6769-436b-8397-fbaa7489fcdf
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=a7048c81-6769-436b-8397-fbaa7489fcdf&type=display
Note
Labeler-specific (Mylan).
Source text (exact source wording)
Store at 20° to 25°C (68° to 77°F). [See USP Controlled Room Temperature.]
Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.
Dispense in a tight, light-resistant container as defined in the USP using a child-resistant closure.
Boxed warning
This label has no boxed warning. The warning about stopping atenolol suddenly is in the WARNINGS section.
Section
The Mylan label has no Boxed Warning section (confirmed by reading the full label text).
Source
DailyMed label, Mylan Pharmaceuticals Inc. atenolol tablets, set ID a7048c81-6769-436b-8397-fbaa7489fcdf
Cessation of therapy warning note
Not a boxed warning in this label; see warnings_and_precautions.
Source text (exact source wording)
NONE
Contraindications
Do not use with a slow heart rate (sinus bradycardia), heart block worse than first degree, cardiogenic shock, or obvious heart failure.
Section
CONTRAINDICATIONS
Source
DailyMed label, Mylan Pharmaceuticals Inc. atenolol tablets, set ID a7048c81-6769-436b-8397-fbaa7489fcdf
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=a7048c81-6769-436b-8397-fbaa7489fcdf&type=display
Source text (exact source wording)
Atenolol tablets are contraindicated in sinus bradycardia, heart block greater than first degree, cardiogenic shock, and overt cardiac failure. (See WARNINGS.)
Do not use if you have ever had an allergic reaction to atenolol or anything in the tablet.
Section
CONTRAINDICATIONS
Source
DailyMed label, Mylan Pharmaceuticals Inc. atenolol tablets, set ID a7048c81-6769-436b-8397-fbaa7489fcdf
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=a7048c81-6769-436b-8397-fbaa7489fcdf&type=display
Source text (exact source wording)
Atenolol tablets are contraindicated in those patients with a history of hypersensitivity to the atenolol or any of the drug product’s components.
Warnings and precautions
Atenolol can make heart failure worse and, over time, can lead to heart failure in some people without a history of it. If signs of heart failure appear, treatment is needed, and atenolol should be withdrawn if the failure continues.
Heading
Cardiac Failure
Section
WARNINGS
Source
DailyMed label, Mylan Pharmaceuticals Inc. atenolol tablets, set ID a7048c81-6769-436b-8397-fbaa7489fcdf
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=a7048c81-6769-436b-8397-fbaa7489fcdf&type=display
Source text (exact source wording)
Sympathetic stimulation is necessary in supporting circulatory function in congestive heart failure, and beta blockade carries the potential hazard of further depressing myocardial contractility and precipitating more severe failure.
In patients with acute myocardial infarction, cardiac failure which is not promptly and effectively controlled by 80 mg of intravenous furosemide or equivalent therapy is a contraindication to beta-blocker treatment.
In Patients Without a History of Cardiac Failure
Continued depression of the myocardium with beta-blocking agents over a period of time can, in some cases, lead to cardiac failure. At the first sign or symptom of impending cardiac failure, patients should be treated appropriately according to currently recommended guidelines, and the response observed closely. If cardiac failure continues despite adequate treatment, atenolol tablets should be withdrawn. (See DOSAGE AND ADMINISTRATION.)
In patients with acute myocardial infarction, cardiac failure which is not promptly and effectively controlled by 80 mg of intravenous furosemide or equivalent therapy is a contraindication to beta-blocker treatment.
In Patients Without a History of Cardiac Failure
Continued depression of the myocardium with beta-blocking agents over a period of time can, in some cases, lead to cardiac failure. At the first sign or symptom of impending cardiac failure, patients should be treated appropriately according to currently recommended guidelines, and the response observed closely. If cardiac failure continues despite adequate treatment, atenolol tablets should be withdrawn. (See DOSAGE AND ADMINISTRATION.)
Do not stop atenolol suddenly if you have coronary artery disease. Sudden stopping has been linked to worse angina, heart attack and dangerous heart rhythms. When stopping is planned, patients should be watched closely and limit physical activity. The label says it may be prudent not to stop abruptly even when atenolol is used only for high blood pressure.
Heading
Cessation of Therapy with Atenolol Tablets
Section
WARNINGS
Source
DailyMed label, Mylan Pharmaceuticals Inc. atenolol tablets, set ID a7048c81-6769-436b-8397-fbaa7489fcdf
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=a7048c81-6769-436b-8397-fbaa7489fcdf&type=display
Source text (exact source wording)
Patients with coronary artery disease, who are being treated with atenolol tablets, should be advised against abrupt discontinuation of therapy. Severe exacerbation of angina and the occurrence of myocardial infarction and ventricular arrhythmias have been reported in angina patients following the abrupt discontinuation of therapy with beta-blockers. The last two complications may occur with or without preceding exacerbation of the angina pectoris. As with other beta-blockers, when discontinuation of atenolol tablets is planned, the patients should be carefully observed and advised to limit physical activity to a minimum. If the angina worsens or acute coronary insufficiency develops, it is recommended that atenolol tablets be promptly reinstituted, at least temporarily. Because coronary artery disease is common and may be unrecognized, it may be prudent not to discontinue atenolol tablets therapy abruptly even in patients treated only for hypertension. (See DOSAGE AND ADMINISTRATION.)
Using atenolol with verapamil or diltiazem can cause a slow heartbeat and heart block. People with existing conduction problems or weak heart function are at higher risk.
Heading
Concomitant Use of Calcium Channel Blockers
Section
WARNINGS
Source
DailyMed label, Mylan Pharmaceuticals Inc. atenolol tablets, set ID a7048c81-6769-436b-8397-fbaa7489fcdf
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=a7048c81-6769-436b-8397-fbaa7489fcdf&type=display
Source text (exact source wording)
Bradycardia and heart block can occur and the left ventricular end diastolic pressure can rise when beta-blockers are administered with verapamil or diltiazem. Patients with pre-existing conduction abnormalities or left ventricular dysfunction are particularly susceptible. (See PRECAUTIONS.)
People with airway-tightening lung disease should in general not take beta-blockers. Atenolol may be used with caution if other treatments fail, at the lowest possible dose starting at 50 mg, with a bronchodilator available.
Heading
Bronchospastic Diseases
Section
WARNINGS
Source
DailyMed label, Mylan Pharmaceuticals Inc. atenolol tablets, set ID a7048c81-6769-436b-8397-fbaa7489fcdf
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=a7048c81-6769-436b-8397-fbaa7489fcdf&type=display
Source text (exact source wording)
PATIENTS WITH BRONCHOSPASTIC DISEASE SHOULD, IN GENERAL, NOT RECEIVE BETA-BLOCKERS. Because of its relative beta1 selectivity, however, atenolol tablets may be used with caution in patients with bronchospastic disease who do not respond to, or cannot tolerate, other antihypertensive treatment. Since beta1 selectivity is not absolute, the lowest possible dose of atenolol tablets should be used with therapy initiated at 50 mg and a beta2-stimulating agent (bronchodilator) should be made available. If dosage must be increased, dividing the dose should be considered in order to achieve lower peak blood levels.
Long-term beta-blocker treatment should not routinely be stopped before major surgery, but it can add to the risks of anesthesia and surgery.
Heading
Major Surgery
Section
WARNINGS
Source
DailyMed label, Mylan Pharmaceuticals Inc. atenolol tablets, set ID a7048c81-6769-436b-8397-fbaa7489fcdf
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=a7048c81-6769-436b-8397-fbaa7489fcdf&type=display
Source text (exact source wording)
Chronically administered beta-blocking therapy should not be routinely withdrawn prior to major surgery, however the impaired ability of the heart to respond to reflex adrenergic stimuli may augment the risks of general anesthesia and surgical procedures.
Atenolol can hide early warning signs of low blood sugar, such as a fast heartbeat, and raise the risk of severe or long-lasting low blood sugar. This is more likely in people with diabetes or who are fasting or vomiting. Severe low blood sugar needs emergency treatment.
Heading
Hypoglycemia
Section
WARNINGS
Source
DailyMed label, Mylan Pharmaceuticals Inc. atenolol tablets, set ID a7048c81-6769-436b-8397-fbaa7489fcdf
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=a7048c81-6769-436b-8397-fbaa7489fcdf&type=display
Source text (exact source wording)
Beta-blockers may prevent early warning signs of hypoglycemia, such as tachycardia, and increase the risk for severe or prolonged hypoglycemia at any time during treatment, especially in patients with diabetes mellitus or children and patients who are fasting (i.e., surgery, not eating regularly, or are vomiting). If severe hypoglycemia occurs, patients should be instructed to seek emergency treatment.
Atenolol can hide signs of an overactive thyroid. Stopping it suddenly might trigger a thyroid storm, so close monitoring is needed.
Heading
Thyrotoxicosis
Section
WARNINGS
Source
DailyMed label, Mylan Pharmaceuticals Inc. atenolol tablets, set ID a7048c81-6769-436b-8397-fbaa7489fcdf
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=a7048c81-6769-436b-8397-fbaa7489fcdf&type=display
Source text (exact source wording)
Beta-adrenergic blockade may mask certain clinical signs (e.g., tachycardia) of hyperthyroidism. Abrupt withdrawal of beta blockade might precipitate a thyroid storm; therefore, patients suspected of developing thyrotoxicosis from whom atenolol tablets therapy is to be withdrawn should be monitored closely. (See DOSAGE AND ADMINISTRATION.)
Atenolol should not be given to people with an untreated pheochromocytoma.
Heading
Untreated Pheochromocytoma
Section
WARNINGS
Source
DailyMed label, Mylan Pharmaceuticals Inc. atenolol tablets, set ID a7048c81-6769-436b-8397-fbaa7489fcdf
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=a7048c81-6769-436b-8397-fbaa7489fcdf&type=display
Source text (exact source wording)
Atenolol tablets should not be given to patients with untreated pheochromocytoma.
People already on a beta-blocker need careful evaluation first. Atenolol may worsen circulation problems in the arms and legs and should be used with caution when kidney function is reduced.
Heading
P:General and Impaired Renal Function
Section
PRECAUTIONS
Source
DailyMed label, Mylan Pharmaceuticals Inc. atenolol tablets, set ID a7048c81-6769-436b-8397-fbaa7489fcdf
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=a7048c81-6769-436b-8397-fbaa7489fcdf&type=display
Source text (exact source wording)
Patients already on a beta-blocker must be evaluated carefully before atenolol tablets are administered. Initial and subsequent atenolol tablets dosages can be adjusted downward depending on clinical observations including pulse and blood pressure. Atenolol tablets may aggravate peripheral arterial circulatory disorders.
The drug should be used with caution in patients with impaired renal function. (See DOSAGE AND ADMINISTRATION.)
The drug should be used with caution in patients with impaired renal function. (See DOSAGE AND ADMINISTRATION.)
People with a history of severe allergic reactions may react more severely while on a beta-blocker and may not respond to the usual doses of epinephrine.
Heading
P:Anaphylaxis
Section
PRECAUTIONS
Source
DailyMed label, Mylan Pharmaceuticals Inc. atenolol tablets, set ID a7048c81-6769-436b-8397-fbaa7489fcdf
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=a7048c81-6769-436b-8397-fbaa7489fcdf&type=display
Source text (exact source wording)
While taking beta-blockers, patients with a history of anaphylactic reaction to a variety of allergens may have a more severe reaction on repeated challenge, either accidental, diagnostic or therapeutic. Such patients may be unresponsive to the usual doses of epinephrine used to treat the allergic reaction.
Pregnancy and breastfeeding
Atenolol can cause harm to an unborn baby. Use starting in the second trimester has been linked to babies who are small for their age. The first trimester has not been studied. Babies of mothers taking atenolol at delivery or while breastfeeding may be at risk for low blood sugar and a slow heartbeat. Atenolol passes into breast milk, and a slow heartbeat has been reported in breastfed infants. Talk to your doctor if pregnant or breastfeeding.
Section
WARNINGS (Pregnancy and Fetal Injury) and PRECAUTIONS (Nursing Mothers)
Source
DailyMed label, Mylan Pharmaceuticals Inc. atenolol tablets, set ID a7048c81-6769-436b-8397-fbaa7489fcdf
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=a7048c81-6769-436b-8397-fbaa7489fcdf&type=display
Medlineplus
Source
MedlinePlus
Source url
https://medlineplus.gov/druginfo/meds/a684031.html
Source text (exact source wording)
tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking atenolol, call your doctor immediately.
Source text (exact source wording)
Atenolol can cause fetal harm when administered to a pregnant woman. Atenolol crosses the placental barrier and appears in cord blood. Administration of atenolol, starting in the second trimester of pregnancy, has been associated with the birth of infants that are small for gestational age. No studies have been performed on the use of atenolol in the first trimester and the possibility of fetal injury cannot be excluded. If this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to the fetus.
Neonates born to mothers who are receiving atenolol tablets at parturition or breastfeeding may be at risk for hypoglycemia and bradycardia. Caution should be exercised when atenolol tablets are administered during pregnancy or to a woman who is breastfeeding. (See PRECAUTIONS: Nursing Mothers.) [WARNINGS, Pregnancy and Fetal Injury]
Nursing Mothers: Atenolol is excreted in human breast milk at a ratio of 1.5 to 6.8 when compared to the concentration in plasma. Caution should be exercised when atenolol tablets are administered to a nursing woman. Clinically significant bradycardia has been reported in breastfed infants. Premature infants, or infants with impaired renal function, may be more likely to develop adverse effects. [PRECAUTIONS, Nursing Mothers]
Neonates born to mothers who are receiving atenolol tablets at parturition or breastfeeding may be at risk for hypoglycemia and bradycardia. Caution should be exercised when atenolol tablets are administered during pregnancy or to a woman who is breastfeeding. (See PRECAUTIONS: Nursing Mothers.) [WARNINGS, Pregnancy and Fetal Injury]
Nursing Mothers: Atenolol is excreted in human breast milk at a ratio of 1.5 to 6.8 when compared to the concentration in plasma. Caution should be exercised when atenolol tablets are administered to a nursing woman. Clinically significant bradycardia has been reported in breastfed infants. Premature infants, or infants with impaired renal function, may be more likely to develop adverse effects. [PRECAUTIONS, Nursing Mothers]
Side effects
Common
The label does not name a most-common list. It says most side effects have been mild and temporary. See the table under less_common for the label's percentages.
Section
ADVERSE REACTIONS
Source
DailyMed label, Mylan Pharmaceuticals Inc. atenolol tablets, set ID a7048c81-6769-436b-8397-fbaa7489fcdf
Threshold
The label gives no 'most common' list and no stated incidence threshold. It says: 'Most adverse effects have been mild and transient.'
Less common
In the label's tables the highest rates among people given atenolol were tiredness (26% of 399 in the combined volunteered and elicited studies versus 13% on placebo), dizziness (13% versus 6%), cold extremities (12% versus 5%) and depression (12% versus 9%). Bradycardia was 3% versus 0%. Where atenolol and placebo rates are similar, the label says a link to atenolol is uncertain.
Section
ADVERSE REACTIONS (hypertension controlled-studies table)
Source
DailyMed label, Mylan Pharmaceuticals Inc. atenolol tablets, set ID a7048c81-6769-436b-8397-fbaa7489fcdf
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=a7048c81-6769-436b-8397-fbaa7489fcdf&type=display
Note
Table values copied as printed. The label says: 'Where frequency of adverse effects of atenolol tablets and placebo is similar, causal relationship to atenolol tablets is uncertain.' Order and wording of rows follow the label table; layout flattened to text.
Source text (exact source wording)
Volunteered (U.S. Studies) Atenolol (n = 164) % / Placebo (n = 206) %; Total-Volunteered and Elicited (Foreign + U.S. Studies) Atenolol (n = 399) % / Placebo (n = 407) %:
Bradycardia 3 / 0 ; 3 / 0
Cold Extremities 0 / 0.5 ; 12 / 5
Postural Hypotension 2 / 1 ; 4 / 5
Leg Pain 0 / 0.5 ; 3 / 1
Dizziness 4 / 1 ; 13 / 6
Vertigo 2 / 0.5 ; 2 / 0.2
Light-headedness 1 / 0 ; 3 / 0.7
Tiredness 0.6 / 0.5 ; 26 / 13
Fatigue 3 / 1 ; 6 / 5
Lethargy 1 / 0 ; 3 / 0.7
Drowsiness 0.6 / 0 ; 2 / 0.5
Depression 0.6 / 0.5 ; 12 / 9
Dreaming 0 / 0 ; 3 / 1
Diarrhea 2 / 0 ; 3 / 2
Nausea 4 / 1 ; 3 / 1
Wheeziness 0 / 0 ; 3 / 3
Dyspnea 0.6 / 1 ; 6 / 4
Bradycardia 3 / 0 ; 3 / 0
Cold Extremities 0 / 0.5 ; 12 / 5
Postural Hypotension 2 / 1 ; 4 / 5
Leg Pain 0 / 0.5 ; 3 / 1
Dizziness 4 / 1 ; 13 / 6
Vertigo 2 / 0.5 ; 2 / 0.2
Light-headedness 1 / 0 ; 3 / 0.7
Tiredness 0.6 / 0.5 ; 26 / 13
Fatigue 3 / 1 ; 6 / 5
Lethargy 1 / 0 ; 3 / 0.7
Drowsiness 0.6 / 0 ; 2 / 0.5
Depression 0.6 / 0.5 ; 12 / 9
Dreaming 0 / 0 ; 3 / 1
Diarrhea 2 / 0 ; 3 / 2
Nausea 4 / 1 ; 3 / 1
Wheeziness 0 / 0 ; 3 / 3
Dyspnea 0.6 / 1 ; 6 / 4
Acute mi table note
After a heart attack, slow heartbeat and low blood pressure happened more often with atenolol than without it. These usually responded to atropine and/or to withholding further doses. The label says heart failure was not increased.
Section
ADVERSE REACTIONS, Acute Myocardial Infarction
Source
DailyMed label, Mylan Pharmaceuticals Inc. atenolol tablets, set ID a7048c81-6769-436b-8397-fbaa7489fcdf
Source text (exact source wording)
In a series of investigations in the treatment of acute myocardial infarction, bradycardia and hypotension occurred more commonly, as expected for any beta-blocker, in atenolol-treated patients than in control patients. However, these usually responded to atropine and/or to withholding further dosage of atenolol. The incidence of heart failure was not increased by atenolol. Inotropic agents were infrequently used.
Serious
Label
Reports after the drug was on the market include raised liver tests, hallucinations, psychoses, low platelets, fainting with low blood pressure, worse psoriasis, sick sinus syndrome, lupus syndrome and Raynaud's phenomenon. The label lists other effects as well.
Section
ADVERSE REACTIONS (postmarketing)
Source
DailyMed label, Mylan Pharmaceuticals Inc. atenolol tablets, set ID a7048c81-6769-436b-8397-fbaa7489fcdf
Source text (exact source wording)
During postmarketing experience with atenolol tablets, the following have been reported in temporal relationship to the use of the drug: elevated liver enzymes and/or bilirubin, hallucinations, headache, impotence, Peyronie’s disease, postural hypotension which may be associated with syncope, psoriasiform rash or exacerbation of psoriasis, psychoses, purpura, reversible alopecia, thrombocytopenia, visual disturbance, sick sinus syndrome, and dry mouth. Atenolol tablets, like other beta-blockers, has been associated with the development of antinuclear antibodies (ANA), lupus syndrome, and Raynaud’s phenomenon.
Medlineplus
Call your doctor right away or get emergency care for shortness of breath, wheezing, swelling of the hands, feet, ankles or lower legs, unusual weight gain, fainting, or a rapid, pounding or irregular heartbeat.
Section
What side effects can this medication cause?
Source
MedlinePlus
Source url
https://medlineplus.gov/druginfo/meds/a684031.html
Source text (exact source wording)
Some side effects can be serious. If you experience any of these symptoms call your doctor immediately or get emergency medical treatment:
shortness of breath
wheezing
swelling of the hands, feet, ankles, or lower legs
unusual weight gain
fainting
rapid, pounding, or irregular heartbeat
shortness of breath
wheezing
swelling of the hands, feet, ankles, or lower legs
unusual weight gain
fainting
rapid, pounding, or irregular heartbeat
Led to discontinuation
Note
Label gives no discontinuation-rate figure for the hypertension studies; for ISIS-1 it gives reasons for reduced dosage (not copied here).
Interactions
Drugs
Drugs such as reserpine can add to atenolol's effect. Watch for low blood pressure and a very slow heartbeat that may cause dizziness or fainting.
Name
Catecholamine-depleting drugs (e.g., reserpine)
Section
PRECAUTIONS, Drug Interactions
Source
DailyMed label, Mylan Pharmaceuticals Inc. atenolol tablets, set ID a7048c81-6769-436b-8397-fbaa7489fcdf
Source text (exact source wording)
Catecholamine-depleting drugs (e.g., reserpine) may have an additive effect when given with beta-blocking agents. Patients treated with atenolol tablets plus a catecholamine depletor should therefore be closely observed for evidence of hypotension and/or marked bradycardia which may produce vertigo, syncope, or postural hypotension.
Verapamil or diltiazem with atenolol can cause a slow heartbeat and heart block.
Name
Calcium channel blockers (verapamil, diltiazem)
Section
WARNINGS, Concomitant Use of Calcium Channel Blockers
Source
DailyMed label, Mylan Pharmaceuticals Inc. atenolol tablets, set ID a7048c81-6769-436b-8397-fbaa7489fcdf
Source text (exact source wording)
Bradycardia and heart block can occur and the left ventricular end diastolic pressure can rise when beta-blockers are administered with verapamil or diltiazem. Patients with pre-existing conduction abnormalities or left ventricular dysfunction are particularly susceptible. (See PRECAUTIONS.)
Disopyramide with a beta-blocker has been linked to a very slow heartbeat, heart stopping and heart failure.
Name
Disopyramide
Section
PRECAUTIONS, Drug Interactions
Source
DailyMed label, Mylan Pharmaceuticals Inc. atenolol tablets, set ID a7048c81-6769-436b-8397-fbaa7489fcdf
Source text (exact source wording)
Disopyramide is a Type I antiarrhythmic drug with potent negative inotropic and chronotropic effects. Disopyramide has been associated with severe bradycardia, asystole and heart failure when administered with beta-blockers.
Amiodarone can add to the heart-rate slowing of beta-blockers.
Name
Amiodarone
Section
PRECAUTIONS, Drug Interactions
Source
DailyMed label, Mylan Pharmaceuticals Inc. atenolol tablets, set ID a7048c81-6769-436b-8397-fbaa7489fcdf
Source text (exact source wording)
Amiodarone is an antiarrhythmic agent with negative chronotropic properties that may be additive to those seen with beta-blockers.
Beta-blockers can worsen the rebound high blood pressure that may follow stopping clonidine. The label gives timing instructions for stopping or switching; follow your prescriber's directions.
Name
Clonidine
Section
PRECAUTIONS, Drug Interactions
Source
DailyMed label, Mylan Pharmaceuticals Inc. atenolol tablets, set ID a7048c81-6769-436b-8397-fbaa7489fcdf
Source text (exact source wording)
Beta-blockers may exacerbate the rebound hypertension which can follow the withdrawal of clonidine. If the two drugs are coadministered, the beta-blocker should be withdrawn several days before the gradual withdrawal of clonidine. If replacing clonidine by beta-blocker therapy, the introduction of beta-blockers should be delayed for several days after clonidine administration has stopped.
Drugs such as indomethacin may weaken the blood-pressure-lowering effect of beta-blockers.
Name
Prostaglandin synthase inhibiting drugs (e.g., indomethacin)
Section
PRECAUTIONS, Drug Interactions
Source
DailyMed label, Mylan Pharmaceuticals Inc. atenolol tablets, set ID a7048c81-6769-436b-8397-fbaa7489fcdf
Source text (exact source wording)
Concomitant use of prostaglandin synthase inhibiting drugs, e.g., indomethacin, may decrease the hypotensive effects of beta-blockers.
Information on atenolol with aspirin is limited. Studies listed in the label do not suggest an interaction in the heart attack setting.
Name
Aspirin
Section
PRECAUTIONS, Drug Interactions
Source
DailyMed label, Mylan Pharmaceuticals Inc. atenolol tablets, set ID a7048c81-6769-436b-8397-fbaa7489fcdf
Source text (exact source wording)
Information on concurrent usage of atenolol and aspirin is limited. Data from several studies, i.e., TIMI-II, ISIS-2, currently do not suggest any clinical interaction between aspirin and beta-blockers in the acute myocardial infarction setting.
People with past severe allergic reactions may not respond to the usual epinephrine doses while on a beta-blocker.
Name
Epinephrine (in patients with a history of anaphylaxis)
Section
PRECAUTIONS, Drug Interactions
Source
DailyMed label, Mylan Pharmaceuticals Inc. atenolol tablets, set ID a7048c81-6769-436b-8397-fbaa7489fcdf
Source text (exact source wording)
While taking beta-blockers, patients with a history of anaphylactic reaction to a variety of allergens may have a more severe reaction on repeated challenge, either accidental, diagnostic or therapeutic. Such patients may be unresponsive to the usual doses of epinephrine used to treat the allergic reaction.
Digitalis medicines and beta-blockers both slow the heart. Together they can raise the risk of a slow heartbeat.
Name
Digitalis glycosides
Section
PRECAUTIONS, Drug Interactions
Source
DailyMed label, Mylan Pharmaceuticals Inc. atenolol tablets, set ID a7048c81-6769-436b-8397-fbaa7489fcdf
Source text (exact source wording)
Both digitalis glycosides and beta-blockers slow atrioventricular conduction and decrease heart rate. Concomitant use can increase the risk of bradycardia.
Food and alcohol
Name
Diet (MedlinePlus)
Section
What special dietary instructions should I follow?
Source
MedlinePlus
Source url
https://medlineplus.gov/druginfo/meds/a684031.html
Source text (exact source wording)
Unless your doctor tells you otherwise, continue your normal diet.
Patient tips
Label
Patients and caregivers should know there is a risk of low blood sugar if you are fasting or vomiting while on atenolol.
Section
PRECAUTIONS, Information for Patients
Source
DailyMed label, Mylan Pharmaceuticals Inc. atenolol tablets, set ID a7048c81-6769-436b-8397-fbaa7489fcdf
Source text (exact source wording)
Information for Patients - Hypoglycemia
Inform patients or caregivers that there is a risk of hypoglycemia when atenolol tablets are given to patients who are fasting or who are vomiting. Monitor for symptoms of hypoglycemia.
(The Mylan label has no separate Patient Information leaflet section in the text read; this is its 'Information for Patients' subsection.)
Inform patients or caregivers that there is a risk of hypoglycemia when atenolol tablets are given to patients who are fasting or who are vomiting. Monitor for symptoms of hypoglycemia.
(The Mylan label has no separate Patient Information leaflet section in the text read; this is its 'Information for Patients' subsection.)
Medlineplus how to take
Take the tablet by mouth once or twice a day at the same time(s) each day, exactly as prescribed. It controls but does not cure high blood pressure and angina. Full benefit may take 1-2 weeks. Keep taking it even if you feel well, and do not stop without talking to your doctor.
Section
How should this medicine be used?
Source
MedlinePlus
Source url
https://medlineplus.gov/druginfo/meds/a684031.html
Source text (exact source wording)
Atenolol comes as a tablet to take by mouth. It is taken once or twice a day. Take it around the same time(s) every day.
Take atenolol exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Atenolol controls high blood pressure and angina but does not cure them. It may take 1-2 weeks before you feel the full benefit of atenolol. Continue to take atenolol even if you feel well. Do not stop taking atenolol without talking to your doctor.
Take atenolol exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
Atenolol controls high blood pressure and angina but does not cure them. It may take 1-2 weeks before you feel the full benefit of atenolol. Continue to take atenolol even if you feel well. Do not stop taking atenolol without talking to your doctor.
Medlineplus avoid and precautions
Get up slowly from lying down to avoid dizziness and fainting, especially when starting. Atenolol can hide the warning signs of low blood sugar; tell your doctor if you cannot eat or drink normally or are vomiting. Tell your doctor or dentist you take atenolol before surgery.
Section
What special precautions should I follow?
Source
MedlinePlus
Source url
https://medlineplus.gov/druginfo/meds/a684031.html
Source text (exact source wording)
you should know that atenolol may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. This is more common when you first start taking atenolol. To avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up.
you should know that atenolol may increase the risk of hypoglycemia (low blood sugar) and prevent the warning signs and symptoms that would tell you that your blood sugar is low. Let your doctor know if you are unable to eat or drink normally or are vomiting while you are taking atenolol.
if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking atenolol.
you should know that atenolol may increase the risk of hypoglycemia (low blood sugar) and prevent the warning signs and symptoms that would tell you that your blood sugar is low. Let your doctor know if you are unable to eat or drink normally or are vomiting while you are taking atenolol.
if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking atenolol.
Medlineplus when to call
Call your doctor right away or get emergency care for shortness of breath, wheezing, swelling, unusual weight gain, fainting, or a rapid, pounding or irregular heartbeat. Keep your appointments; your blood pressure should be checked regularly and your doctor may ask you to check your pulse.
Section
What side effects can this medication cause? / What other information should I know?
Source
MedlinePlus
Source url
https://medlineplus.gov/druginfo/meds/a684031.html
Source text (exact source wording)
Some side effects can be serious. If you experience any of these symptoms call your doctor immediately or get emergency medical treatment:
shortness of breath
wheezing
swelling of the hands, feet, ankles, or lower legs
unusual weight gain
fainting
rapid, pounding, or irregular heartbeat
Keep all appointments with your doctor. Your blood pressure should be checked regularly to determine your response to atenolol. Your doctor may ask you to check your pulse (heart rate).
shortness of breath
wheezing
swelling of the hands, feet, ankles, or lower legs
unusual weight gain
fainting
rapid, pounding, or irregular heartbeat
Keep all appointments with your doctor. Your blood pressure should be checked regularly to determine your response to atenolol. Your doctor may ask you to check your pulse (heart rate).
Reporting
FDA MedWatch: 1-800-FDA-1088 (www.fda.gov/medwatch). Poison control: 1-800-222-1222.
Alternatives
Class
beta-Adrenergic Blocker [EPC]
Class source
openFDA label endpoint count of openfda.pharm_class_epc.exact for ATENOLOL
Class source url
https://api.fda.gov/drug/label.json?search=openfda.generic_name.exact:"ATENOLOL"&count=openfda.pharm_class_epc.exact
Candidates
- carvedilol
- nadolol
- labetalol
- pindolol
- nebivolol
- timolol
Candidates source
openFDA label endpoint, count of openfda.generic_name.exact where pharm_class_epc is beta-Adrenergic Blocker [EPC] (atenolol-chlorthalidone combination excluded)
Candidates source url
https://api.fda.gov/drug/label.json?search=openfda.pharm_class_epc.exact:"beta-Adrenergic Blocker [EPC]"&count=openfda.generic_name.exact&limit=20
Recommendation
none (no ranking)
Frequently asked questions
Question
What is atenolol used for?
Answer
Atenolol lowers high blood pressure, helps manage long-term angina (chest pain from coronary artery disease), and is used in stable patients with a definite or suspected heart attack to lower the risk of death from heart problems.
Source section
INDICATIONS AND USAGE
Source
DailyMed label, Mylan Pharmaceuticals Inc. atenolol tablets, set ID a7048c81-6769-436b-8397-fbaa7489fcdf
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=a7048c81-6769-436b-8397-fbaa7489fcdf&type=display
Question
How should I take atenolol and how long until it works?
Answer
MedlinePlus says it is a tablet taken by mouth once or twice a day, at about the same time each day, exactly as directed. It may take 1-2 weeks before you feel the full benefit.
Source section
How should this medicine be used?
Source
MedlinePlus
Source url
https://medlineplus.gov/druginfo/meds/a684031.html
Question
What if I miss a dose?
Answer
MedlinePlus says to take it when you remember. If it is almost time for the next dose, skip the missed one. Do not take a double dose.
Source section
What should I do if I forget a dose?
Source
MedlinePlus
Source url
https://medlineplus.gov/druginfo/meds/a684031.html
Question
Should I stop atenolol when my blood pressure is normal or I feel well?
Answer
No. MedlinePlus says to keep taking it even if you feel well and not to stop without talking to your doctor. The label warns that stopping suddenly has been linked to worse angina, heart attack and dangerous heart rhythms in people with coronary artery disease.
Source section
WARNINGS, Cessation of Therapy; MedlinePlus How should this medicine be used?
Source
DailyMed label, Mylan Pharmaceuticals Inc. atenolol tablets, set ID a7048c81-6769-436b-8397-fbaa7489fcdf
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=a7048c81-6769-436b-8397-fbaa7489fcdf&type=display
Question
What are the common side effects?
Answer
The label does not give a most-common list. In its hypertension study table the combined volunteered and elicited rates for atenolol were tiredness 26%, dizziness 13%, cold extremities 12% and depression 12%, and placebo rates were also notable (13%, 6%, 5% and 9%). The label says most side effects have been mild and transient.
Source section
ADVERSE REACTIONS
Source
DailyMed label, Mylan Pharmaceuticals Inc. atenolol tablets, set ID a7048c81-6769-436b-8397-fbaa7489fcdf
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=a7048c81-6769-436b-8397-fbaa7489fcdf&type=display
Question
Is atenolol safe in pregnancy or breastfeeding?
Answer
The label says atenolol can cause fetal harm. Use starting in the second trimester has been associated with infants small for gestational age. It passes into breast milk, and clinically significant bradycardia has been reported in breastfed infants. Talk with your doctor.
Source section
WARNINGS (Pregnancy and Fetal Injury); PRECAUTIONS (Nursing Mothers)
Source
DailyMed label, Mylan Pharmaceuticals Inc. atenolol tablets, set ID a7048c81-6769-436b-8397-fbaa7489fcdf
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=a7048c81-6769-436b-8397-fbaa7489fcdf&type=display
Question
What medicines should I be careful combining with atenolol?
Answer
The label discusses verapamil or diltiazem, reserpine-type drugs, disopyramide, amiodarone, clonidine, indomethacin-type drugs, and digitalis glycosides. Tell your doctor and pharmacist about everything you take.
Source section
PRECAUTIONS, Drug Interactions; WARNINGS
Source
DailyMed label, Mylan Pharmaceuticals Inc. atenolol tablets, set ID a7048c81-6769-436b-8397-fbaa7489fcdf
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=a7048c81-6769-436b-8397-fbaa7489fcdf&type=display
Question
Can atenolol affect blood sugar?
Answer
Yes. The label says beta-blockers may prevent early warning signs of low blood sugar, such as a fast heartbeat, and may increase the risk of severe or prolonged low blood sugar, especially in people with diabetes or who are fasting or vomiting. Severe low blood sugar needs emergency treatment.
Source section
WARNINGS, Hypoglycemia
Source
DailyMed label, Mylan Pharmaceuticals Inc. atenolol tablets, set ID a7048c81-6769-436b-8397-fbaa7489fcdf
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=a7048c81-6769-436b-8397-fbaa7489fcdf&type=display
Sources
- DailyMed atenolol tablets, Mylan Pharmaceuticals Inc. (ANDA073457)
Set id: a7048c81-6769-436b-8397-fbaa7489fcdf · Label effective or revised date: Revised: 2/2026 · Dailymed version date: DailyMed list published_date Mar 20, 2026 · Fetched at: 2026-11-02 · Sections used: Description, Clinical Pharmacology, Indications, Contraindications, Warnings, Precautions, Adverse Reactions, Overdosage, Dosage and Administration, How Supplied - MedlinePlus Atenolol
Label effective or revised date: Last Revised - 03/15/2026 · Fetched at: 2026-11-02 · Sections used: all patient sections - openFDA drug label endpoint (pharmacologic class and candidate list)
Fetched at: 2026-11-02 · Sections used: openfda.pharm_class_epc - DailyMed spls.json list (atenolol)
Fetched at: 2026-11-02 · Sections used: labeler and set ID selection
Information is taken from the cited sources and is for general reference only. It is not medical advice. Report side effects to FDA MedWatch at 1-800-FDA-1088. For a poison emergency call 1-800-222-1222. See prices for this drug