Disulfiram
Generic name: disulfiram · Brand names: Antabuse
Quick facts
Drug class
Section
DESCRIPTION
Medlineplus text
It is in a class of medications called alcohol deterrents.
Source
Alvogen label; MedlinePlus
Source text (exact source wording)
Disulfiram is an alcohol antagonist drug.
Rx or otc
Value
Rx only
Source
Alvogen label, title line 'Rx only'
Forms and strengths
Value
Tablet, 250 mg disulfiram, USP; white, round, unscored, debossed 607 (Alvogen label)
Source
Alvogen label, DESCRIPTION and HOW SUPPLIED
Generic available
Value
Yes. The chosen label is marketing category ANDA, ANDA091681.
Source
Alvogen label, Marketing Information
Common use one line
Used as an aid in the management of selected chronic alcohol patients who want to remain in a state of enforced sobriety (label, INDICATIONS AND USAGE).
What it is used for
Disulfiram helps some people with long-term alcohol problems who want to stay sober. It is not a cure for alcoholism. By itself, without motivation and supportive therapy, it is unlikely to change drinking much.
Section
INDICATIONS AND USAGE
Source
Alvogen label
Source text (exact source wording)
Disulfiram is an aid in the management of selected chronic alcohol patients who want to remain in a state of enforced sobriety so that supportive and psychotherapeutic treatment may be applied to best advantage. Disulfiram is not a cure for alcoholism. When used alone, without proper motivation and supportive therapy, it is unlikely that it will have any substantive effect on the drinking pattern of the chronic alcoholic.
How it works
Disulfiram makes the body very sensitive to alcohol. It blocks the breakdown of alcohol at the acetaldehyde stage, so acetaldehyde in the blood may be 5 to 10 times higher than with the same amount of alcohol alone. This causes a very unpleasant reaction if even small amounts of alcohol are taken.
Section
CLINICAL PHARMACOLOGY
Source
Alvogen label
Source text (exact source wording)
Disulfiram produces a sensitivity to alcohol which results in a highly unpleasant reaction when the patient under treatment ingests even small amounts of alcohol. Disulfiram blocks the oxidation of alcohol at the acetaldehyde stage. During alcohol metabolism following disulfiram intake, the concentration of acetaldehyde occurring in the blood may be 5 to 10 times higher than that found during metabolism of the same amount of alcohol alone.
Dosage: adults
Do not start disulfiram until you have not had alcohol for at least 12 hours. At first, up to 500 mg a day is given as one dose for one to two weeks. The average maintenance dose is 250 mg daily (range, 125 mg to 500 mg) and it should not exceed 500 mg daily. It is usually taken in the morning, but may be taken at bedtime by people who feel sleepy from it.
Section
DOSAGE AND ADMINISTRATION
Source
Alvogen label
Source text (exact source wording)
Disulfiram should never be administered until the patient has abstained from alcohol for at least 12 hours. Initial Dosage Schedule: In the first phase of treatment, a maximum of 500 mg daily is given in a single dose for one to two weeks. Although usually taken in the morning, disulfiram may be taken on retiring by patients who experience a sedative effect. Alternatively, to minimize, or eliminate, the sedative effect, dosage may be adjusted downward. Maintenance Regimen: The average maintenance dose is 250 mg daily (range, 125 mg to 500 mg), it should not exceed 500 mg daily.
Dosage: children
Safety and effectiveness in children have not been established.
Section
PRECAUTIONS, Pediatric Use
Source
Alvogen label
Source text (exact source wording)
Safety and effectiveness in pediatric patients have not been established.
Dosage adjustments
Drug interaction caps
Doses of oral blood thinners (anticoagulants) may need to be adjusted when disulfiram is started or stopped.
Section
PRECAUTIONS, Drug Interactions
Source
Alvogen label
Source text (exact source wording)
It may be necessary to adjust the dosage of oral anticoagulants upon beginning or stopping disulfiram, since disulfiram may prolong prothrombin time.
Elderly
For older patients, dose selection should be cautious, usually starting at the low end of the dosing range, because older people more often have reduced liver, kidney or heart function or other conditions and medicines.
Section
PRECAUTIONS, Geriatric Use
Source
Alvogen label
Source text (exact source wording)
A determination has not been made whether controlled clinical studies of disulfiram included sufficient numbers of subjects aged 65 and over to define a difference in response from younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal or cardiac function, and of concomitant disease or other drug therapy.
Missed dose
Take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed one. Do not take a double dose.
Section
What should I do if I forget a dose?
Source
MedlinePlus https://medlineplus.gov/druginfo/meds/a682602.html (the label has no missed-dose section)
Source text (exact source wording)
Take the missed dose as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Overdose
No specific treatment information is available for disulfiram overdose. In case of overdose call poison control at 1-800-222-1222. If someone has collapsed, had a seizure, has trouble breathing, or can't be awakened, call 911 (MedlinePlus).
Section
OVERDOSAGE
Source
Alvogen label
Medlineplus text
In case of overdose, call the poison control helpline at 1-800-222-1222.
Source text (exact source wording)
No specific information is available on the treatment of overdosage with disulfiram. It is recommended that the physician contact the local Poison Control Center.
Storage
Store at 20°C to 25°C (68°F to 77°F). The label says to dispense in a tight, light-resistant container. MedlinePlus says to keep it in the container it came in, tightly closed, away from heat and moisture, and out of reach of children.
Section
HOW SUPPLIED
Source
Alvogen label (labeler-specific; Bottle of 30 NDC 47781-607-30)
Source text (exact source wording)
Dispense in a tight, light-resistant container as defined in the USP. Store at 20°C to 25°C (68°F to 77°F). [See USP Controlled Room Temperature].
Boxed warning
Disulfiram must never be given to a person who is intoxicated with alcohol, or without the person's full knowledge. The doctor should tell relatives this too.
Section
WARNING (boxed text at top of label)
Source
Alvogen label
Source text (exact source wording)
Disulfiram should never be administered to a patient when he is in a state of alcohol intoxication, or without his full knowledge. The physician should instruct relatives accordingly.
Contraindications
Do not give disulfiram to people who are taking or have recently taken metronidazole, paraldehyde, alcohol, or alcohol-containing products such as cough syrups and tonics.
Section
CONTRAINDICATIONS
Source
Alvogen label
Source text (exact source wording)
Patients who are receiving or have recently received metronidazole, paraldehyde, alcohol, or alcohol-containing preparations, e.g., cough syrups, tonics and the like, should not be given disulfiram.
Disulfiram must not be used with severe myocardial disease or coronary occlusion, psychoses, or hypersensitivity to disulfiram or other thiuram derivatives used in pesticides and rubber vulcanization.
Section
CONTRAINDICATIONS
Source
Alvogen label
Source text (exact source wording)
Disulfiram is contraindicated in the presence of severe myocardial disease or coronary occlusion, psychoses, and hypersensitivity to disulfiram or to other thiuram derivatives used in pesticides and rubber vulcanization.
Warnings and precautions
Patients must be told about the disulfiram-alcohol reaction and warned not to drink secretly. Alcohol hidden in sauces, vinegars, cough mixtures, aftershave lotions and back rubs should be avoided. Reactions may occur with alcohol up to 14 days after taking disulfiram.
Heading
Patient must be informed; hidden alcohol
Section
WARNINGS
Source
Alvogen label
Source text (exact source wording)
The patient must be fully informed of the disulfiram-alcohol reaction. He must be strongly cautioned against surreptitious drinking while taking the drug, and he must be fully aware of the possible consequences. He should be warned to avoid alcohol in disguised forms, i.e., in sauces, vinegars, cough mixtures, and even in aftershave lotions and back rubs. He should also be warned that reactions may occur with alcohol up to 14 days after ingesting disulfiram.
Disulfiram plus even small amounts of alcohol can cause flushing, throbbing headache, trouble breathing, nausea, heavy vomiting, sweating, chest pain, fast heartbeat, low blood pressure, fainting, weakness, dizziness, blurred vision and confusion. Severe reactions can include respiratory depression, cardiovascular collapse, arrhythmias, myocardial infarction, acute congestive heart failure, unconsciousness, convulsions, and death.
Heading
The Disulfiram-Alcohol Reaction
Section
WARNINGS, The Disulfiram-Alcohol Reaction
Source
Alvogen label
Source text (exact source wording)
Disulfiram plus alcohol, even small amounts, produce flushing, throbbing in head and neck, throbbing headache, respiratory difficulty, nausea, copious vomiting, sweating, thirst, chest pain, palpitation, dyspnea, hyperventilation, tachycardia, hypotension, syncope, marked uneasiness, weakness, vertigo, blurred vision, and confusion. In severe reactions there may be respiratory depression, cardiovascular collapse, arrhythmias, myocardial infarction, acute congestive heart failure, unconsciousness, convulsions, and death.
The reaction varies by person and is generally proportional to the amounts of disulfiram and alcohol taken. It lasts from 30 to 60 minutes, to several hours in more severe cases, or as long as there is alcohol in the blood.
Heading
Reaction intensity and duration
Section
WARNINGS, The Disulfiram-Alcohol Reaction
Source
Alvogen label
Source text (exact source wording)
The intensity of the reaction varies with each individual, but is generally proportional to the amounts of disulfiram and alcohol ingested. Mild reactions may occur in the sensitive individual when the blood alcohol concentration is increased to as little as 5 mg to 10 mg per 100 mL. Symptoms are fully developed at 50 mg per 100 mL, and unconsciousness usually results when the blood alcohol level reaches 125 mg to 150 mg. The duration of the reaction varies from 30 to 60 minutes, to several hours in the more severe cases, or as long as there is alcohol in the blood.
Use disulfiram with extreme caution in people with diabetes mellitus, hypothyroidism, epilepsy, cerebral damage, chronic and acute nephritis, or hepatic cirrhosis or insufficiency.
Heading
Concomitant conditions
Section
WARNINGS, Concomitant Conditions
Source
Alvogen label
Source text (exact source wording)
Because of the possibility of an accidental disulfiram-alcohol reaction, disulfiram should be used with extreme caution in patients with any of the following conditions: diabetes mellitus, hypothyroidism, epilepsy, cerebral damage, chronic and acute nephritis, hepatic cirrhosis or insufficiency.
Liver failure leading to transplant or death has been reported. Severe and sometimes fatal hepatitis can develop even after many months of therapy, with or without prior liver problems. Patients should tell their doctor right away about early signs such as fatigue, weakness, malaise, loss of appetite, nausea, vomiting, jaundice or dark urine. Liver function tests at baseline and follow-up (10 to 14 days) are suggested.
Heading
Hepatic toxicity
Section
PRECAUTIONS
Source
Alvogen label
Source text (exact source wording)
Hepatic toxicity including hepatic failure resulting in transplantation or death have been reported. Severe and sometimes fatal hepatitis associated with disulfiram therapy may develop even after many months of therapy. Hepatic toxicity has occurred in patients with or without prior history of abnormal liver function. Patients should be advised to immediately notify their physician of any early symptoms of hepatitis, such as fatigue, weakness, malaise, anorexia, nausea, vomiting, jaundice, or dark urine. Baseline and follow-up liver function tests (10 to 14 days) are suggested to detect any hepatic dysfunction that may result with disulfiram therapy. In addition, a complete blood count and serum chemistries, including liver function tests, should be monitored.
People with a history of rubber contact dermatitis should be evaluated for hypersensitivity to thiuram derivatives before receiving disulfiram.
Heading
Rubber contact dermatitis / thiuram hypersensitivity
Section
PRECAUTIONS
Source
Alvogen label
Source text (exact source wording)
Patients with a history of rubber contact dermatitis should be evaluated for hypersensitivity to thiuram derivatives before receiving disulfiram (see CONTRAINDICATIONS).
Every patient should carry an identification card saying they take disulfiram, describing likely symptoms of the disulfiram-alcohol reaction, and naming the doctor or institution to contact in an emergency.
Heading
Identification card
Section
PRECAUTIONS
Source
Alvogen label
Source text (exact source wording)
It is suggested that every patient under treatment carry an Identification Card stating that he is receiving disulfiram and describing the symptoms most likely to occur as a result of the disulfiram-alcohol reaction. In addition, this card should indicate the physician or institution to be contacted in an emergency.
Patients taking disulfiram should not be exposed to ethylene dibromide or its vapors. Animal research suggested a toxic interaction in rats; a link to humans has not been demonstrated.
Heading
Ethylene dibromide
Section
PRECAUTIONS
Source
Alvogen label
Source text (exact source wording)
Patients taking disulfiram tablets should not be exposed to ethylene dibromide or its vapors. This precaution is based on preliminary results of animal research currently in progress that suggest a toxic interaction between inhaled ethylene dibromide and ingested disulfiram resulting in a higher incidence of tumors and mortality in rats. A correlation between this finding and humans, however, has not been demonstrated.
Alcoholism may come with or be followed by dependence on narcotics or sedatives, and the possibility of starting a new abuse should be considered.
Heading
Possible new dependence
Section
PRECAUTIONS
Source
Alvogen label
Source text (exact source wording)
Alcoholism may accompany or be followed by dependence on narcotics or sedatives. Barbiturates and disulfiram have been administered concurrently without untoward effects; the possibility of initiating a new abuse should be considered.
Pregnancy and breastfeeding
The safe use of disulfiram in pregnancy has not been established; it should be used only when the doctor judges the benefits outweigh the risks. It is not known whether it passes into breast milk, and the label says it should not be given to nursing mothers. MedlinePlus says to tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding.
Section
PRECAUTIONS, Usage In Pregnancy and Nursing Mothers
Source
Alvogen label
Medlineplus text
tell your doctor if you are pregnant, plan to become pregnant, or are breast-feeding. If you become pregnant while taking disulfiram, call your doctor.
Source text (exact source wording)
Usage In Pregnancy: The safe use of this drug in pregnancy has not been established. Therefore, disulfiram should be used during pregnancy only when, in the judgement of the physician, the probable benefits outweigh the possible risks. Nursing Mothers: It is not known whether this drug is excreted in human milk. Since many drugs are so excreted, disulfiram should not be given to nursing mothers.
Side effects
Common
The label gives no percentages. It says a small number of patients may have mild drowsiness, tiredness, impotence, headache, acne-like skin eruptions, allergic dermatitis, or a metallic or garlic-like aftertaste during the first two weeks, and that these usually go away with continued therapy or reduced dosage.
Threshold
none stated in label
Source
Alvogen label
Serious
Label: optic neuritis, peripheral neuritis, polyneuritis and peripheral neuropathy may occur; hepatitis (cholestatic and fulminant) and liver failure leading to transplant or death have been reported; psychotic reactions have been noted. MedlinePlus: call your doctor right away for excessive tiredness, weakness, lack of energy, loss of appetite, lower abdominal pain, vomiting, yellow skin or eyes, dark urine or clay-colored stools.
Section
ADVERSE REACTIONS
Source
Alvogen label
Medlineplus text
Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately: excessive tiredness; weakness; lack of energy; loss of appetite, lower abdominal pain; vomiting; yellowing of the skin or whites of eyes; dark urine; clay-colored stools
Medlineplus source
https://medlineplus.gov/druginfo/meds/a682602.html
Source text (exact source wording)
OPTIC NEURITIS, PERIPHERAL NEURITIS, POLYNEURITIS, AND PERIPHERAL NEUROPATHY MAY OCCUR FOLLOWING ADMINISTRATION OF DISULFIRAM. Multiple cases of hepatitis, including both cholestatic and fulminant hepatitis, as well as hepatic failure resulting in transplantation or death, have been reported with administration of disulfiram. Psychotic reactions have been noted, attributable in most cases to high dosage, combined toxicity (with metronidazole or isoniazid), or to the unmasking of underlying psychoses in patients stressed by the withdrawal of alcohol.
Interactions
Drugs
Use disulfiram with caution in patients taking phenytoin or similar drugs, because the combination can lead to phenytoin intoxication. A baseline phenytoin blood level should be obtained before starting disulfiram, and levels checked on different days afterward.
Name
Phenytoin and its congeners
Section
PRECAUTIONS, Drug Interactions
Source text (exact source wording)
DISULFIRAM SHOULD BE USED WITH CAUTION IN THOSE PATIENTS RECEIVING PHENYTOIN AND ITS CONGENERS, SINCE THE CONCOMITANT ADMINISTRATION OF THESE TWO DRUGS CAN LEAD TO PHENYTOIN INTOXICATION. PRIOR TO ADMINISTERING DISULFIRAM TO A PATIENT ON PHENYTOIN THERAPY, A BASELINE PHENYTOIN SERUM LEVEL SHOULD BE OBTAINED. SUBSEQUENT TO INITIATION OF DISULFIRAM THERAPY, SERUM LEVELS OF PHENYTOIN SHOULD BE DETERMINED ON DIFFERENT DAYS FOR EVIDENCE OF AN INCREASE OR FOR A CONTINUING RISE IN LEVELS. INCREASED PHENYTOIN LEVELS SHOULD BE TREATED WITH APPROPRIATE DOSAGE ADJUSTMENT.
Doses of oral anticoagulants may need adjusting when disulfiram is started or stopped, because disulfiram may prolong prothrombin time.
Name
Oral anticoagulants
Section
PRECAUTIONS, Drug Interactions
Source text (exact source wording)
It may be necessary to adjust the dosage of oral anticoagulants upon beginning or stopping disulfiram, since disulfiram may prolong prothrombin time.
Patients taking isoniazid with disulfiram should be watched for unsteady gait or marked changes in mental status. Disulfiram should be stopped if such signs appear.
Name
Isoniazid
Section
PRECAUTIONS, Drug Interactions
Source text (exact source wording)
Patients taking isoniazid when disulfiram is given should be observed for the appearance of unsteady gait or marked changes in mental status, the disulfiram should be discontinued if such signs appear.
Patients receiving or recently receiving metronidazole or paraldehyde should not be given disulfiram.
Name
Metronidazole
Section
CONTRAINDICATIONS
Source text (exact source wording)
Patients who are receiving or have recently received metronidazole, paraldehyde, alcohol, or alcohol-containing preparations, e.g., cough syrups, tonics and the like, should not be given disulfiram.
Disulfiram appears to slow the breakdown of certain drugs, which may raise their blood levels and the chance of toxicity.
Name
General effect on other drugs
Section
PRECAUTIONS, Drug Interactions
Source text (exact source wording)
Disulfiram appears to decrease the rate at which certain drugs are metabolized and therefore may increase the blood levels and the possibility of clinical toxicity of drugs given concomitantly.
Food and alcohol
Do not drink alcohol while taking disulfiram. Avoid sauces, vinegars and other foods or products containing alcohol. Reactions may occur up to 14 days after the last dose per the label; MedlinePlus says to avoid alcohol for several weeks after stopping.
Name
Alcohol, including hidden alcohol
Section
WARNINGS; MedlinePlus dietary instructions
Medlineplus text
Do not drink any alcoholic beverages (including wine, beer, and medications that contain alcohol such as cough syrup) while taking disulfiram, during the 12-hour period before you take your first dose, and for several weeks after stopping the drug. Avoid sauces, vinegars, and all foods and beverages containing alcohol.
Source text (exact source wording)
He should be warned to avoid alcohol in disguised forms, i.e., in sauces, vinegars, cough mixtures, and even in aftershave lotions and back rubs. He should also be warned that reactions may occur with alcohol up to 14 days after ingesting disulfiram.
Other
Avoid exposure to ethylene dibromide or its vapors.
Name
Ethylene dibromide
Section
PRECAUTIONS
Source text (exact source wording)
Patients taking disulfiram tablets should not be exposed to ethylene dibromide or its vapors.
MedlinePlus says not to contact or breathe fumes of paint, paint thinner, varnish, shellac and other alcohol-containing products, and to be careful with aftershave, cologne and rubbing alcohol on the skin.
Name
Alcohol-containing products on skin, paint and similar fumes
Section
What other information should I know? (MedlinePlus)
Source text (exact source wording)
Do not come in contact with or breathe the fumes of paint, paint thinner, varnish, shellac, and other products containing alcohol. Exercise caution when applying alcohol-containing products (e.g., aftershave lotions, colognes, and rubbing alcohol) to your skin.
Patient tips
Medlineplus
Take one tablet-dose once a day exactly as directed. If you cannot swallow tablets, crush them and mix with water, coffee, tea, milk, soft drink or fruit juice. Do not stop without talking to your doctor. It may make you drowsy, so do not drive or run machinery until you know how it affects you. Tell any surgeon or dentist you take it. Keep all doctor and lab appointments and carry an identification card.
Section
How should this medicine be used? / What special precautions should I follow? / What other information should I know?
Source
MedlinePlus https://medlineplus.gov/druginfo/meds/a682602.html
Source text (exact source wording)
Disulfiram comes in tablets to take by mouth. Take it once a day. Take disulfiram exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor. If you cannot swallow the tablets, crush them and mix the medication with water, coffee, tea, milk, soft drink, or fruit juice. Disulfiram controls chronic alcoholism but does not cure it. Do not stop taking disulfiram without talking to your doctor. you should know that this drug may make you drowsy. Do not drive a car or operate machinery until you know how this drug affects you. if you are having surgery, including dental surgery, tell the doctor or dentist that you are taking disulfiram. Keep all appointments with your doctor and the laboratory. Always carry an identification card stating that you are taking disulfiram and indicating the doctor or institution to be contacted in an emergency.
Alternatives
Pharmacologic class from label
alcohol antagonist drug (Alvogen label, DESCRIPTION); alcohol deterrents (MedlinePlus)
Openfda pharm class epc
not checked
Note
No recommendation made.
Frequently asked questions
Question
What is disulfiram used for?
Answer
Disulfiram is an aid in the management of selected chronic alcohol patients who want to remain in a state of enforced sobriety. It is not a cure for alcoholism.
Source section
INDICATIONS AND USAGE
Source
Alvogen label
Question
How does disulfiram work?
Answer
It blocks the breakdown of alcohol at the acetaldehyde stage, so acetaldehyde in the blood may be 5 to 10 times higher than with the same amount of alcohol alone. This causes an unpleasant reaction when alcohol is taken.
Source section
CLINICAL PHARMACOLOGY
Source
Alvogen label
Question
Can I drink alcohol while taking disulfiram?
Answer
No. Even small amounts of alcohol can cause a reaction, and reactions may occur up to 14 days after the last dose. Hidden alcohol in sauces, vinegars, cough mixtures, aftershave lotions and back rubs should also be avoided.
Source section
WARNINGS
Source
Alvogen label
Question
What is the usual dose?
Answer
The first phase is a maximum of 500 mg daily in a single dose for one to two weeks. The average maintenance dose is 250 mg daily (range, 125 mg to 500 mg) and it should not exceed 500 mg daily. Do not start until you have abstained from alcohol for at least 12 hours.
Source section
DOSAGE AND ADMINISTRATION
Source
Alvogen label
Question
What should I do if I miss a dose?
Answer
Take it as soon as you remember. If it is almost time for the next dose, skip the missed dose. Do not take a double dose.
Source section
What should I do if I forget a dose?
Source
MedlinePlus
Question
What side effects can disulfiram cause?
Answer
In a small number of patients: mild drowsiness, tiredness, impotence, headache, acne-like eruptions, allergic dermatitis, or a metallic or garlic-like aftertaste during the first two weeks. Serious effects include hepatitis and liver failure, optic neuritis, peripheral neuropathy and psychotic reactions. Call your doctor right away for yellow skin or eyes or dark urine.
Source section
ADVERSE REACTIONS
Source
Alvogen label; MedlinePlus
Question
Is disulfiram safe in pregnancy or while breastfeeding?
Answer
The safe use in pregnancy has not been established, and it should be used only if the doctor judges the benefits outweigh the risks. The label says it should not be given to nursing mothers.
Source section
PRECAUTIONS, Usage In Pregnancy and Nursing Mothers
Source
Alvogen label
Question
Should I stop taking it if I feel better?
Answer
Do not stop taking disulfiram without talking to your doctor. The label says daily, uninterrupted administration must be continued until the patient is fully recovered socially and a basis for permanent self-control is established.
Source section
DOSAGE AND ADMINISTRATION, Duration of Therapy; MedlinePlus
Source
Alvogen label; MedlinePlus
Sources
- DailyMed Disulfiram Tablets, USP (Alvogen Inc.)
Set id: b90f8ff4-4fb3-46ab-8149-cb55f24a4044 · Label effective or revised date: Revised: 1/2026 (package label also shows Rev. 12/2025) · Dailymed version date: Nov 17, 2025 (published_date in DailyMed list) · Fetched at: 2026-11-02 · Sections used: all label sections - MedlinePlus Disulfiram
Set id: n/a · Label effective or revised date: Last Revised - 08/15/2026 · Fetched at: 2026-11-02 · Sections used: patient wording, missed dose, precautions, side effects, brand names - DailyMed list API (disulfiram)
Fetched at: 2026-11-02 · Sections used: set IDs and publish dates - Alternate label: Sigmapharm Laboratories
Set id: 40f5497f-fe84-43b2-8ff4-32d59edf3917 · Label effective or revised date: Revised: 8/2024 · Fetched at: 2026-11-02 · Sections used: revised date only
Information is taken from the cited sources and is for general reference only. It is not medical advice. Report side effects to FDA MedWatch at 1-800-FDA-1088. For a poison emergency call 1-800-222-1222. See prices for this drug