Furosemide
Generic name: furosemide · Brand names: Lasix
Quick facts
Drug class
Value
Loop Diuretic [EPC]
Source
openFDA label API count of openfda.pharm_class_epc for generic_name FUROSEMIDE (last_updated 2026-10-30)
Source url
https://api.fda.gov/drug/label.json?search=openfda.generic_name.exact:"FUROSEMIDE"&count=openfda.pharm_class_epc.exact
Rx or otc
Value
Rx only
Source
DailyMed label header: 'Rx Only'
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=462e8917-cbe0-f4f9-e063-6394a90ab4ff&type=display
Forms and strengths
Text
Furosemide is available in 20 mg, 40 mg and 80 mg tablets for oral administration.
Section
DESCRIPTION
Source
DailyMed label, Granulation Technology, Inc., set ID 462e8917-cbe0-f4f9-e063-6394a90ab4ff
Generic available
Value
Yes. The chosen label is a generic furosemide tablet label (Marketing Category NDA, NDA018569, per the label's Marketing Information). MedlinePlus lists Lasix as a brand name.
Source
DailyMed label, Granulation Technology, Inc., set ID 462e8917-cbe0-f4f9-e063-6394a90ab4ff
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=462e8917-cbe0-f4f9-e063-6394a90ab4ff&type=display
Common use one line
Treats edema (fluid buildup) and high blood pressure.
Scope note
Covers furosemide ORAL TABLETS only. Furosemide oral solution and injection not covered.
What it is used for
Furosemide treats edema (extra fluid in the body) linked to heart failure, liver cirrhosis and kidney disease in adults and children. Adults can also take it for high blood pressure, alone or with other blood pressure medicines.
Section
INDICATIONS AND USAGE
Source
DailyMed label, Granulation Technology, Inc., set ID 462e8917-cbe0-f4f9-e063-6394a90ab4ff
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=462e8917-cbe0-f4f9-e063-6394a90ab4ff&type=display
Source text (exact source wording)
Edema: Furosemide is indicated in adults and pediatric patients for the treatment of edema associated with congestive heart failure, cirrhosis of the liver, and renal disease, including the nephrotic syndrome. Furosemide is particularly useful when an agent with greater diuretic potential is desired. Hypertension: Oral Furosemide may be used in adults for the treatment of hypertension alone or in combination with other antihypertensive agents. Hypertensive patients who cannot be adequately controlled with thiazides will probably also not be adequately controlled with Furosemide alone.
How it works
Furosemide works in the kidney by blocking the reabsorption of sodium and chloride, so the body passes more salt and water in urine.
Section
CLINICAL PHARMACOLOGY
Source
DailyMed label, Granulation Technology, Inc., set ID 462e8917-cbe0-f4f9-e063-6394a90ab4ff
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=462e8917-cbe0-f4f9-e063-6394a90ab4ff&type=display
Source text (exact source wording)
It has been demonstrated that furosemide inhibits primarily the absorption of sodium and chloride not only in the proximal and distal tubules but also in the loop of Henle. The high degree of efficacy is largely due to the unique site of action. The action on the distal tubule is independent of any inhibitory effect on carbonic anhydrase and aldosterone.
Dosage: adults
For edema, adults usually start at 20 mg to 80 mg by mouth as a single dose. If needed, the same dose can be given 6 to 8 hours later, or the dose can be raised by 20 mg or 40 mg. The label says the single dose is then given once or twice daily, and up to 600 mg/day may be used in severe edema. For high blood pressure the usual starting dose is 80 mg, usually divided into 40 mg twice a day, then adjusted. Dosing is set by the prescriber.
Section
DOSAGE AND ADMINISTRATION (Edema, Adults; Hypertension, Adults)
Source
DailyMed label, Granulation Technology, Inc., set ID 462e8917-cbe0-f4f9-e063-6394a90ab4ff
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=462e8917-cbe0-f4f9-e063-6394a90ab4ff&type=display
Source text (exact source wording)
Edema - Adults: The usual initial dose of furosemide is 20 mg to 80 mg given orally as a single dose. Ordinarily a prompt diuresis ensues. If needed, the same dose can be administered 6 to 8 hours later or the dose may be increased. The dose may be raised by 20 mg or 40 mg and given not sooner than 6 to 8 hours after the previous dose until the desired diuretic effect has been obtained. The individually determined single dose should then be given once or twice daily (e.g., at 8 am and 2 pm). The dose of furosemide may be carefully titrated up to 600 mg/day in patients with clinically severe edematous states. Edema may be most efficiently and safely mobilized by giving furosemide on 2 to 4 consecutive days each week. When doses exceeding 80 mg/day are given for prolonged periods, careful clinical observation and laboratory monitoring are particularly advisable. Hypertension - Adults: The usual initial dose of furosemide for hypertension is 80 mg, usually divided into 40 mg orally twice a day. Dosage should then be adjusted according to response. If response is not satisfactory, add other antihypertensive agents. Changes in blood pressure must be carefully monitored when furosemide is used with other antihypertensive drugs, especially during initial therapy. To prevent excessive drop in blood pressure, the dosage of other agents should be reduced by at least 50 % when furosemide is added to the regimen.
Dosage: children
For children with edema the usual starting dose is 2 mg/kg of body weight as a single dose. It may be raised by 1 or 2 mg/kg no sooner than 6 to 8 hours later. Doses above 6 mg/kg are not recommended.
Section
DOSAGE AND ADMINISTRATION (Edema, Pediatric Patients)
Source
DailyMed label, Granulation Technology, Inc., set ID 462e8917-cbe0-f4f9-e063-6394a90ab4ff
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=462e8917-cbe0-f4f9-e063-6394a90ab4ff&type=display
Source text (exact source wording)
The usual initial dose of oral furosemide in pediatric patients is 2 mg/kg body weight, given orally as a single dose. If the diuretic response is not satisfactory after the initial dose, dosage may be increased by 1 or 2 mg/kg no sooner than 6 to 8 hours after the previous dose. Doses greater than 6 mg/kg body weight are not recommended. For maintenance therapy in pediatric patients, the dose should be adjusted to the minimum effective level.
Dosage adjustments
Drug interaction caps
When furosemide is added to other blood pressure medicines, the label says the dose of the other medicines should be reduced by at least 50 %.
Section
DOSAGE AND ADMINISTRATION (Hypertension, Adults)
Source
DailyMed label, Granulation Technology, Inc., set ID 462e8917-cbe0-f4f9-e063-6394a90ab4ff
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=462e8917-cbe0-f4f9-e063-6394a90ab4ff&type=display
Source text (exact source wording)
To prevent excessive drop in blood pressure, the dosage of other agents should be reduced by at least 50 % when furosemide is added to the regimen.
Kidney
Section
WARNINGS
Source
DailyMed label, Granulation Technology, Inc., set ID 462e8917-cbe0-f4f9-e063-6394a90ab4ff
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=462e8917-cbe0-f4f9-e063-6394a90ab4ff&type=display
Source text (exact source wording)
If increasing azotemia and oliguria occur during treatment of severe progressive renal disease, Furosemide should be discontinued.
Liver
Section
WARNINGS
Source
DailyMed label, Granulation Technology, Inc., set ID 462e8917-cbe0-f4f9-e063-6394a90ab4ff
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=462e8917-cbe0-f4f9-e063-6394a90ab4ff&type=display
Source text (exact source wording)
In patients with hepatic cirrhosis and ascites, Furosemide therapy is best initiated in the hospital.
Elderly
For older adults the label says dose selection should be cautious, usually starting at the low end of the dosing range.
Section
DOSAGE AND ADMINISTRATION (Geriatric Patients)
Source
DailyMed label, Granulation Technology, Inc., set ID 462e8917-cbe0-f4f9-e063-6394a90ab4ff
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=462e8917-cbe0-f4f9-e063-6394a90ab4ff&type=display
Source text (exact source wording)
In general, dose selection for the elderly patient should be cautious, usually starting at the low end of the dosing range
Missed dose
Take it when you remember. If it is almost time for the next dose, skip the missed one. Do not take a double dose. (The DailyMed label has no missed-dose section.)
Section
What should I do if I forget a dose?
Source
MedlinePlus Furosemide (Last Revised 04/15/2025)
Source url
https://medlineplus.gov/druginfo/meds/a682858.html
Source text (exact source wording)
Take the missed dose as soon as you remember it. However, if it is almost time for your next dose, skip the missed dose and continue your regular dosing schedule. Do not take a double dose to make up for a missed one.
Overdose
Too much furosemide can cause dehydration, low blood volume, low blood pressure and electrolyte problems. Treatment is supportive. Poison control: 1-800-222-1222 (MedlinePlus). Symptoms listed by MedlinePlus: extreme thirst, dry mouth, dizziness, confusion, extreme tiredness, vomiting, stomach cramps.
Section
OVERDOSAGE
Source
DailyMed label, Granulation Technology, Inc., set ID 462e8917-cbe0-f4f9-e063-6394a90ab4ff
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=462e8917-cbe0-f4f9-e063-6394a90ab4ff&type=display
Poison control
Source
MedlinePlus Furosemide, In case of emergency/overdose
Source url
https://medlineplus.gov/druginfo/meds/a682858.html
Source text (exact source wording)
In case of overdose, call the poison control helpline at 1-800-222-1222.
Source text (exact source wording)
The principal signs and symptoms of overdose with Furosemide are dehydration, blood volume reduction, hypotension, electrolyte imbalance, hypokalemia and hypochloremic alkalosis, and are extensions of its diuretic action. Treatment of overdosage is supportive and consists of replacement of excessive fluid and electrolyte losses. Serum electrolytes, carbon dioxide level and blood pressure should be determined frequently. Hemodialysis does not accelerate furosemide elimination.
Storage
Store at 68º to 77ºF (20º to 25ºC) in a tight, light-resistant container. Light may slightly discolor the tablets. This is the labeler's text. MedlinePlus separately says to keep it away from excess heat and moisture, not in the bathroom.
Section
HOW SUPPLIED (Granulation Technology label)
Source
DailyMed label, Granulation Technology, Inc., set ID 462e8917-cbe0-f4f9-e063-6394a90ab4ff
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=462e8917-cbe0-f4f9-e063-6394a90ab4ff&type=display
Source text (exact source wording)
Exposure to light might cause a slight discoloration. Discolored tablets should not be dispensed. Store at 68º to 77ºF (20º to 25ºC) [See USP Controlled Room Temperature]. Dispense and store in a tight, light-resistant container.
Boxed warning
Furosemide is a strong diuretic. Too much can cause a large loss of water and electrolytes, so careful medical supervision is needed and the dose must fit the patient.
Present
YES (label shows this text under a heading 'WARNING' at the top of the label; the page text does not say 'BOXED WARNING', so whether it is formatted as a box is not confirmed)
Section
WARNING
Source
DailyMed label, Granulation Technology, Inc., set ID 462e8917-cbe0-f4f9-e063-6394a90ab4ff
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=462e8917-cbe0-f4f9-e063-6394a90ab4ff&type=display
Source text (exact source wording)
Furosemide is a potent diuretic which, if given in excessive amounts, can lead to a profound diuresis with water and electrolyte depletion. Therefore, careful medical supervision is required and dose and dose schedule must be adjusted to the individual patient’s needs [see DOSAGE AND ADMINISTRATION].
Contraindications
Do not use furosemide if you make no urine (anuria) or have had an allergic reaction to furosemide.
Section
CONTRAINDICATIONS
Source
DailyMed label, Granulation Technology, Inc., set ID 462e8917-cbe0-f4f9-e063-6394a90ab4ff
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=462e8917-cbe0-f4f9-e063-6394a90ab4ff&type=display
Source text (exact source wording)
Furosemide is contraindicated in patients with anuria and in patients with a history of hypersensitivity to furosemide.
Warnings and precautions
In cirrhosis with ascites, treatment is best started in the hospital. Sudden fluid and electrolyte changes may trigger hepatic coma, so close watching is needed.
Heading
Hepatic cirrhosis, hepatic coma, electrolyte depletion
Section
WARNINGS
Source
DailyMed label, Granulation Technology, Inc., set ID 462e8917-cbe0-f4f9-e063-6394a90ab4ff
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=462e8917-cbe0-f4f9-e063-6394a90ab4ff&type=display
Source text (exact source wording)
In patients with hepatic cirrhosis and ascites, Furosemide therapy is best initiated in the hospital. In hepatic coma and in states of electrolyte depletion, therapy should not be instituted until the basic condition is improved. Sudden alterations of fluid and electrolyte balance in patients with cirrhosis may precipitate hepatic coma; therefore, strict observation is necessary during the period of diuresis. Supplemental potassium chloride and, if required, an aldosterone antagonist are helpful in preventing hypokalemia and metabolic alkalosis.
If kidney problems get worse during treatment of severe kidney disease, furosemide should be stopped.
Heading
Severe progressive renal disease
Section
WARNINGS
Source
DailyMed label, Granulation Technology, Inc., set ID 462e8917-cbe0-f4f9-e063-6394a90ab4ff
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=462e8917-cbe0-f4f9-e063-6394a90ab4ff&type=display
Source text (exact source wording)
If increasing azotemia and oliguria occur during treatment of severe progressive renal disease, Furosemide should be discontinued.
Ringing in the ears and hearing loss, sometimes permanent, have been reported. Risk is higher with severe kidney impairment, higher than recommended doses, low blood protein, or certain other drugs.
Heading
Hearing problems (ototoxicity)
Section
WARNINGS
Source
DailyMed label, Granulation Technology, Inc., set ID 462e8917-cbe0-f4f9-e063-6394a90ab4ff
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=462e8917-cbe0-f4f9-e063-6394a90ab4ff&type=display
Source text (exact source wording)
Cases of tinnitus and reversible or irreversible hearing impairment and deafness have been reported. Reports usually indicate that Furosemide ototoxicity is associated with rapid injection, severe renal impairment, the use of higher than recommended doses, hypoproteinemia or concomitant therapy with aminoglycoside antibiotics, ethacrynic acid, or other ototoxic drugs.
Too much urine output can cause dehydration, low blood volume and low electrolytes, especially in older adults and with higher doses.
Heading
Dehydration and electrolyte depletion
Section
PRECAUTIONS - General
Source
DailyMed label, Granulation Technology, Inc., set ID 462e8917-cbe0-f4f9-e063-6394a90ab4ff
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=462e8917-cbe0-f4f9-e063-6394a90ab4ff&type=display
Source text (exact source wording)
Excessive diuresis may cause dehydration and blood volume reduction with circulatory collapse and possibly vascular thrombosis and embolism, particularly in elderly patients. As with any effective diuretic, electrolyte depletion may occur during Furosemide therapy, especially in patients receiving higher doses and a restricted salt intake. Hypokalemia may develop with Furosemide, especially with brisk diuresis, inadequate oral electrolyte intake, when cirrhosis is present, or during concomitant use of corticosteroids, ACTH, licorice in large amounts, or prolonged use of laxatives.
Furosemide can raise blood sugar and uric acid. People allergic to sulfonamides may also be allergic to furosemide. Lupus may flare.
Heading
Blood sugar, uric acid, sulfonamide allergy, lupus
Section
PRECAUTIONS - General
Source
DailyMed label, Granulation Technology, Inc., set ID 462e8917-cbe0-f4f9-e063-6394a90ab4ff
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=462e8917-cbe0-f4f9-e063-6394a90ab4ff&type=display
Source text (exact source wording)
Increases in blood glucose and alterations in glucose tolerance tests (with abnormalities of the fasting and 2-hour postprandial sugar) have been observed, and rarely, precipitation of diabetes mellitus has been reported. Asymptomatic hyperuricemia can occur and gout may rarely be precipitated. Patients allergic to sulfonamides may also be allergic to Furosemide. The possibility exists of exacerbation or activation of systemic lupus erythematosus.
People who have trouble emptying the bladder need careful monitoring, especially at the start.
Heading
Urinary retention
Section
PRECAUTIONS - General
Source
DailyMed label, Granulation Technology, Inc., set ID 462e8917-cbe0-f4f9-e063-6394a90ab4ff
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=462e8917-cbe0-f4f9-e063-6394a90ab4ff&type=display
Source text (exact source wording)
In patients with severe symptoms of urinary retention (because of bladder emptying disorders, prostatic hyperplasia, urethral narrowing), the administration of furosemide can cause acute urinary retention related to increased production and retention of urine. Thus, these patients require careful monitoring, especially during the initial stages of treatment.
Blood tests of electrolytes and kidney function are done often in the first few months and periodically after.
Heading
Laboratory monitoring
Section
PRECAUTIONS - Laboratory Tests
Source
DailyMed label, Granulation Technology, Inc., set ID 462e8917-cbe0-f4f9-e063-6394a90ab4ff
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=462e8917-cbe0-f4f9-e063-6394a90ab4ff&type=display
Source text (exact source wording)
Serum electrolytes (particularly potassium), CO 2, creatinine and BUN should be determined frequently during the first few months of Furosemide therapy and periodically thereafter.
In premature infants, and in some children under 4 years of age treated long term, furosemide may cause kidney calcium deposits or stones.
Heading
Premature infants and children
Section
PRECAUTIONS - Pediatric Use
Source
DailyMed label, Granulation Technology, Inc., set ID 462e8917-cbe0-f4f9-e063-6394a90ab4ff
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=462e8917-cbe0-f4f9-e063-6394a90ab4ff&type=display
Source text (exact source wording)
In premature infants Furosemide may precipitate nephrocalcinosis/nephrolithiasis. Nephrocalcinosis/nephrolithiasis has also been observed in children under 4 years of age with no history of prematurity who have been treated chronically with Furosemide.
Skin may be more sensitive to sunlight. People with high blood pressure should avoid products that can raise blood pressure, such as some over-the-counter appetite and cold products.
Heading
Sun sensitivity and blood pressure products
Section
PRECAUTIONS - Information for Patients
Source
DailyMed label, Granulation Technology, Inc., set ID 462e8917-cbe0-f4f9-e063-6394a90ab4ff
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=462e8917-cbe0-f4f9-e063-6394a90ab4ff&type=display
Source text (exact source wording)
The skin of some patients may be more sensitive to the effects of sunlight while taking furosemide. Hypertensive patients should avoid medications that may increase blood pressure, including over-the-counter products for appetite suppression and cold symptoms.
Pregnancy and breastfeeding
Pregnancy
There are no adequate studies in pregnant women. Use only if the potential benefit justifies the potential risk to the fetus, and fetal growth needs monitoring.
Section
PRECAUTIONS - Pregnancy
Source
DailyMed label, Granulation Technology, Inc., set ID 462e8917-cbe0-f4f9-e063-6394a90ab4ff
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=462e8917-cbe0-f4f9-e063-6394a90ab4ff&type=display
Source text (exact source wording)
There are no adequate and well-controlled studies in pregnant women. Furosemide should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Treatment during pregnancy requires monitoring of fetal growth because of the potential for higher birth weights.
Breastfeeding
Furosemide appears in breast milk, so caution is advised, and it may reduce milk production.
Section
PRECAUTIONS - Nursing Mothers
Source
DailyMed label, Granulation Technology, Inc., set ID 462e8917-cbe0-f4f9-e063-6394a90ab4ff
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=462e8917-cbe0-f4f9-e063-6394a90ab4ff&type=display
Source text (exact source wording)
Because it appears in breast milk, caution should be exercised when Furosemide is administered to a nursing mother. Furosemide may inhibit lactation.
Medlineplus
Tell your doctor if you are pregnant, plan to be, or are breast-feeding.
Section
What special precautions should I follow?
Source
MedlinePlus Furosemide (Last Revised 04/15/2025)
Source url
https://medlineplus.gov/druginfo/meds/a682858.html
Source text (exact source wording)
tell your doctor if you are pregnant, plan to become pregnant. If you become pregnant while taking furosemide, call your doctor. tell your doctor if you are breast-feeding. Furosemide may affect your milk supply.
Side effects
Common
The label does not say which reactions are most common, so none are listed as common from the label.
Section
ADVERSE REACTIONS
Source
DailyMed label, Granulation Technology, Inc., set ID 462e8917-cbe0-f4f9-e063-6394a90ab4ff
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=462e8917-cbe0-f4f9-e063-6394a90ab4ff&type=display
Medlineplus tell doctor if severe
MedlinePlus lists frequent urination, blurred vision, headache, constipation and diarrhea as side effects to report if severe or persistent.
Section
What side effects can this medication cause?
Source
MedlinePlus Furosemide (Last Revised 04/15/2025)
Source url
https://medlineplus.gov/druginfo/meds/a682858.html
Source text (exact source wording)
Tell your doctor if any of these symptoms are severe or do not go away: frequent urination; blurred vision; headache; constipation; diarrhea
Less common
Source
DailyMed label, Granulation Technology, Inc., set ID 462e8917-cbe0-f4f9-e063-6394a90ab4ff
Label full list
The label lists reactions by body system, from most severe to least severe, without saying how often they occur.
Section
ADVERSE REACTIONS
Source
DailyMed label, Granulation Technology, Inc., set ID 462e8917-cbe0-f4f9-e063-6394a90ab4ff
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=462e8917-cbe0-f4f9-e063-6394a90ab4ff&type=display
Source text (exact source wording)
Gastrointestinal System Reactions: hepatic encephalopathy in patients with hepatocellular insufficiency; pancreatitis; jaundice (intrahepatic cholestatic jaundice); increased liver enzymes; anorexia; oral and gastric irritation; cramping; diarrhea; constipation; nausea; vomiting. Systemic Hypersensitivity Reactions: severe anaphylactic or anaphylactoid reactions (e.g., with shock); systemic vasculitis; interstitial nephritis; necrotizing angiitis. Central Nervous System Reactions: tinnitus and hearing loss; paresthesias; vertigo; dizziness; headache; blurred vision; xanthopsia. Hematologic Reactions: aplastic anemia; thrombocytopenia; agranulocytosis; hemolytic anemia; leukopenia; anemia; eosinophilia. Dermatologic-Hypersensitivity Reactions: toxic epidermal necrolysis; Stevens-Johnson Syndrome; erythema multiforme; drug rash with eosinophilia and systemic symptoms; acute generalized exanthematous pustulosis; exfoliative dermatitis; bullous pemphigoid; purpura; photosensitivity; rash; pruritis; urticaria. Cardiovascular Reaction: Orthostatic hypotension may occur and be aggravated by alcohol, barbiturates, or narcotics. Increase in cholesterol and triglyceride serum levels. Other Reactions: hyperglycemia; glycosuria; hyperuricemia; muscle spasm; weakness; restlessness; urinary bladder spasm; thrombophlebitis; fever. Whenever adverse reactions are moderate or severe, Furosemide dosage should be reduced or therapy withdrawn.
Serious
Label
Serious reactions in the label include severe allergic reactions, blood disorders, serious skin reactions, pancreatitis, and hearing loss.
Section
ADVERSE REACTIONS and WARNINGS
Source
DailyMed label, Granulation Technology, Inc., set ID 462e8917-cbe0-f4f9-e063-6394a90ab4ff
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=462e8917-cbe0-f4f9-e063-6394a90ab4ff&type=display
Source text (exact source wording)
severe anaphylactic or anaphylactoid reactions (e.g., with shock); systemic vasculitis; interstitial nephritis; necrotizing angiitis; aplastic anemia; thrombocytopenia; agranulocytosis; hemolytic anemia; toxic epidermal necrolysis; Stevens-Johnson Syndrome; pancreatitis; tinnitus and hearing loss
Medlineplus
MedlinePlus says to call your doctor right away or get emergency help for these symptoms.
Section
What side effects can this medication cause?
Source
MedlinePlus Furosemide (Last Revised 04/15/2025)
Source url
https://medlineplus.gov/druginfo/meds/a682858.html
Source text (exact source wording)
Some side effects can be serious. If you have any of these symptoms, call your doctor immediately or seek emergency medical treatment: decreased urination; dry mouth; thirst; nausea; vomiting; weakness; drowsiness; confusion; muscle pain or cramps; or rapid or pounding heartbeats; fever; ringing in the ears, loss of hearing; itching, rash, hives, blisters or peeling skin, difficulty breathing or swallowing; yellowing of the skin or eyes
Reporting
To report SUSPECTED ADVERSE REACTIONS, contact FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.
Interactions
Drugs
May raise the risk of hearing damage. Avoid except in life-threatening situations.
Name
Aminoglycoside antibiotics
Section
PRECAUTIONS - Drug Interactions
Source
DailyMed label, Granulation Technology, Inc., set ID 462e8917-cbe0-f4f9-e063-6394a90ab4ff
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=462e8917-cbe0-f4f9-e063-6394a90ab4ff&type=display
Source text (exact source wording)
Furosemide may increase the ototoxic potential of aminoglycoside antibiotics, especially in the presence of impaired renal function. Except in life-threatening situations, avoid this combination.
Should not be used together because of possible hearing damage.
Name
Ethacrynic acid
Section
PRECAUTIONS - Drug Interactions
Source
DailyMed label, Granulation Technology, Inc., set ID 462e8917-cbe0-f4f9-e063-6394a90ab4ff
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=462e8917-cbe0-f4f9-e063-6394a90ab4ff&type=display
Source text (exact source wording)
Furosemide should not be used concomitantly with ethacrynic acid because of the possibility of ototoxicity.
High-dose salicylates may cause toxicity at lower doses.
Name
Salicylates
Section
PRECAUTIONS - Drug Interactions
Source
DailyMed label, Granulation Technology, Inc., set ID 462e8917-cbe0-f4f9-e063-6394a90ab4ff
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=462e8917-cbe0-f4f9-e063-6394a90ab4ff&type=display
Source text (exact source wording)
Patients receiving high doses of salicylates concomitantly with Furosemide, as in rheumatic disease, may experience salicylate toxicity at lower doses because of competitive renal excretory sites.
Risk of hearing damage when given together.
Name
Cisplatin
Section
PRECAUTIONS - Drug Interactions
Source
DailyMed label, Granulation Technology, Inc., set ID 462e8917-cbe0-f4f9-e063-6394a90ab4ff
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=462e8917-cbe0-f4f9-e063-6394a90ab4ff&type=display
Source text (exact source wording)
There is a risk of ototoxic effects if cisplatin and Furosemide are given concomitantly.
Lithium generally should not be given with diuretics because of high risk of lithium toxicity.
Name
Lithium
Section
PRECAUTIONS - Drug Interactions
Source
DailyMed label, Granulation Technology, Inc., set ID 462e8917-cbe0-f4f9-e063-6394a90ab4ff
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=462e8917-cbe0-f4f9-e063-6394a90ab4ff&type=display
Source text (exact source wording)
Lithium generally should not be given with diuretics because they reduce lithium’s renal clearance and add a high risk of lithium toxicity.
May cause severe low blood pressure and worse kidney function.
Name
ACE inhibitors / angiotensin receptor blockers
Section
PRECAUTIONS - Drug Interactions
Source
DailyMed label, Granulation Technology, Inc., set ID 462e8917-cbe0-f4f9-e063-6394a90ab4ff
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=462e8917-cbe0-f4f9-e063-6394a90ab4ff&type=display
Source text (exact source wording)
Furosemide combined with angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers may lead to severe hypotension and deterioration in renal function, including renal failure.
Sucralfate may reduce furosemide's effect. Take them at least two hours apart.
Name
Sucralfate
Section
PRECAUTIONS - Drug Interactions
Source
DailyMed label, Granulation Technology, Inc., set ID 462e8917-cbe0-f4f9-e063-6394a90ab4ff
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=462e8917-cbe0-f4f9-e063-6394a90ab4ff&type=display
Source text (exact source wording)
Simultaneous administration of sucralfate and Furosemide tablets may reduce the natriuretic and antihypertensive effects of Furosemide. The intake of Furosemide and sucralfate should be separated by at least two hours.
Using chloral hydrate with furosemide is not recommended.
Name
Chloral hydrate
Section
PRECAUTIONS - Drug Interactions
Source
DailyMed label, Granulation Technology, Inc., set ID 462e8917-cbe0-f4f9-e063-6394a90ab4ff
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=462e8917-cbe0-f4f9-e063-6394a90ab4ff&type=display
Source text (exact source wording)
Use of Furosemide concomitantly with chloral hydrate is therefore not recommended.
Phenytoin interferes with furosemide's action in the kidney.
Name
Phenytoin
Section
PRECAUTIONS - Drug Interactions
Source
DailyMed label, Granulation Technology, Inc., set ID 462e8917-cbe0-f4f9-e063-6394a90ab4ff
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=462e8917-cbe0-f4f9-e063-6394a90ab4ff&type=display
Source text (exact source wording)
Phenytoin interferes directly with renal action of Furosemide.
NSAIDs may affect kidney tests and weight. Indomethacin may reduce furosemide's effect.
Name
NSAIDs, aspirin, indomethacin
Section
PRECAUTIONS - Drug Interactions
Source
DailyMed label, Granulation Technology, Inc., set ID 462e8917-cbe0-f4f9-e063-6394a90ab4ff
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=462e8917-cbe0-f4f9-e063-6394a90ab4ff&type=display
Source text (exact source wording)
There are case reports of patients who developed increased BUN, serum creatinine and serum potassium levels, and weight gain when furosemide was used in conjunction with NSAIDs. Literature reports indicate that coadministration of indomethacin may reduce the natriuretic and antihypertensive effects of Furosemide in some patients by inhibiting prostaglandin synthesis.
Higher risk of gouty arthritis.
Name
Cyclosporine
Section
PRECAUTIONS - Drug Interactions
Source
DailyMed label, Granulation Technology, Inc., set ID 462e8917-cbe0-f4f9-e063-6394a90ab4ff
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=462e8917-cbe0-f4f9-e063-6394a90ab4ff&type=display
Source text (exact source wording)
Concomitant use of cyclosporine and Furosemide is associated with increased risk of gouty arthritis secondary to Furosemide-induced hyperurecemia and cyclosporine impairment of renal urate excretion.
Low potassium risk is higher with these. Digitalis effects on the heart may worsen if potassium is low.
Name
Corticosteroids, ACTH, laxatives, licorice, digitalis (low potassium)
Section
PRECAUTIONS - General
Source
DailyMed label, Granulation Technology, Inc., set ID 462e8917-cbe0-f4f9-e063-6394a90ab4ff
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=462e8917-cbe0-f4f9-e063-6394a90ab4ff&type=display
Source text (exact source wording)
Hypokalemia may develop with Furosemide, especially with brisk diuresis, inadequate oral electrolyte intake, when cirrhosis is present, or during concomitant use of corticosteroids, ACTH, licorice in large amounts, or prolonged use of laxatives. Digitalis therapy may exaggerate metabolic effects of hypokalemia, especially myocardial effects.
Food and alcohol
Dizziness on standing may be made worse by alcohol, barbiturates or narcotics.
Name
Alcohol (orthostatic hypotension)
Section
ADVERSE REACTIONS
Source
DailyMed label, Granulation Technology, Inc., set ID 462e8917-cbe0-f4f9-e063-6394a90ab4ff
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=462e8917-cbe0-f4f9-e063-6394a90ab4ff&type=display
Source text (exact source wording)
Orthostatic hypotension may occur and be aggravated by alcohol, barbiturates, or narcotics.
Follow any low-salt or potassium-rich diet instructions your doctor gives you carefully.
Name
Low-salt / potassium-rich foods
Section
What special dietary instructions should I follow?
Source
MedlinePlus Furosemide
Source url
https://medlineplus.gov/druginfo/meds/a682858.html
Source text (exact source wording)
If your doctor prescribes a low-salt or low-sodium diet, or to eat or drink increased amounts of potassium-rich foods (e.g., bananas, prunes, raisins, and orange juice) in your diet, follow these instructions carefully.
Name
Grapefruit
Other
If you have high blood pressure, avoid over-the-counter appetite and cold products that can raise blood pressure.
Name
Antihypertensive products
Section
PRECAUTIONS - Information for Patients
Source
DailyMed label, Granulation Technology, Inc., set ID 462e8917-cbe0-f4f9-e063-6394a90ab4ff
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=462e8917-cbe0-f4f9-e063-6394a90ab4ff&type=display
Source text (exact source wording)
Hypertensive patients should avoid medications that may increase blood pressure, including over-the-counter products for appetite suppression and cold symptoms.
Patient tips
Medlineplus
Furosemide controls but does not cure these conditions. Keep taking it even if you feel well and do not stop without talking to your doctor. Protect your skin from the sun, stand up slowly, and keep your appointments and blood tests.
Section
How should this medicine be used? / What special precautions should I follow?
Source
MedlinePlus Furosemide (Last Revised 04/15/2025)
Source url
https://medlineplus.gov/druginfo/meds/a682858.html
Source text (exact source wording)
Furosemide controls high blood pressure and edema but does not cure these conditions. Continue to take furosemide even if you feel well. Do not stop taking furosemide without talking to your doctor. plan to avoid unnecessary or prolonged exposure to sunlight and to wear protective clothing, sunglasses, and sunscreen. Furosemide may make your skin sensitive to sunlight. To avoid this problem, get out of bed slowly, resting your feet on the floor for a few minutes before standing up. Alcohol can add to these side effects. Keep all appointments with your doctor and the laboratory. Your blood pressure should be checked regularly, and blood tests should be done occasionally.
Label
Get up slowly. You may need potassium supplements or diet changes. If you have diabetes, furosemide may raise blood glucose.
Section
PRECAUTIONS - Information for Patients
Source
DailyMed label, Granulation Technology, Inc., set ID 462e8917-cbe0-f4f9-e063-6394a90ab4ff
Source url
https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=462e8917-cbe0-f4f9-e063-6394a90ab4ff&type=display
Source text (exact source wording)
The postural hypotension that sometimes occurs can usually be managed by getting up slowly. Potassium supplements and/or dietary measures may be needed to control or avoid hypokalemia. Patients with diabetes mellitus should be told that furosemide may increase blood glucose levels and thereby affect urine glucose tests.
Alternatives
Class
Loop Diuretic [EPC]
Class source
openFDA label API (openfda.pharm_class_epc)
Class source url
https://api.fda.gov/drug/label.json?search=openfda.pharm_class_epc.exact:"Loop Diuretic [EPC]"&count=openfda.generic_name.exact&limit=10
Candidates
- bumetanide
- torsemide
- ethacrynic acid
Note
Listed only because openFDA shows them in the same pharmacologic class. No recommendation.
Frequently asked questions
Question
What is furosemide used for?
Answer
Furosemide treats edema (extra fluid) linked to congestive heart failure, cirrhosis of the liver, and renal disease. Adults can also use the tablets for high blood pressure.
Source section
INDICATIONS AND USAGE
Source
DailyMed label, Granulation Technology, Inc., set ID 462e8917-cbe0-f4f9-e063-6394a90ab4ff
Question
How is furosemide usually dosed for adults with edema?
Answer
The label says the usual initial dose is 20 mg to 80 mg given orally as a single dose, and it can be raised by 20 mg or 40 mg, with a single dose then given once or twice daily. Your prescriber sets your dose.
Source section
DOSAGE AND ADMINISTRATION
Source
DailyMed label, Granulation Technology, Inc., set ID 462e8917-cbe0-f4f9-e063-6394a90ab4ff
Question
What should I do if I miss a dose?
Answer
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed one. Do not take a double dose.
Source section
What should I do if I forget a dose?
Source
MedlinePlus Furosemide
Question
Does alcohol affect furosemide?
Answer
The label says orthostatic hypotension may occur and be aggravated by alcohol, barbiturates, or narcotics. MedlinePlus says alcohol can add to dizziness and fainting when you stand up.
Source section
ADVERSE REACTIONS; MedlinePlus precautions
Source
DailyMed label and MedlinePlus
Question
Can I take furosemide with sucralfate?
Answer
The label says sucralfate may reduce furosemide's effect and the two should be separated by at least two hours.
Source section
PRECAUTIONS - Drug Interactions
Source
DailyMed label, Granulation Technology, Inc., set ID 462e8917-cbe0-f4f9-e063-6394a90ab4ff
Question
Is furosemide safe in pregnancy or while breastfeeding?
Answer
The label says there are no adequate studies in pregnant women and it should be used only if the potential benefit justifies the potential risk to the fetus. It appears in breast milk and may inhibit lactation.
Source section
PRECAUTIONS - Pregnancy; Nursing Mothers
Source
DailyMed label, Granulation Technology, Inc., set ID 462e8917-cbe0-f4f9-e063-6394a90ab4ff
Question
Should I stop taking furosemide when I feel well?
Answer
MedlinePlus says furosemide controls but does not cure these conditions, to continue even if you feel well, and not to stop without talking to your doctor.
Source section
How should this medicine be used?
Source
MedlinePlus Furosemide
Question
Can furosemide affect my hearing?
Answer
Cases of tinnitus and reversible or irreversible hearing impairment and deafness have been reported. Tell your doctor right away about ringing in the ears or hearing loss.
Source section
WARNINGS; MedlinePlus side effects
Source
DailyMed label and MedlinePlus
Sources
- DailyMed furosemide tablets, Granulation Technology, Inc. (chosen label)
Set id: 462e8917-cbe0-f4f9-e063-6394a90ab4ff · Label effective or revised date: Revised: 6/2026 (also 'Rev. June 2026') · Dailymed version date: Jun 18, 2026 (DailyMed list publish date) · Fetched at: 2026-11-02 · Sections used: WARNING, DESCRIPTION, CLINICAL PHARMACOLOGY, INDICATIONS AND USAGE, CONTRAINDICATIONS, WARNINGS, PRECAUTIONS, ADVERSE REACTIONS, DOSAGE AND ADMINISTRATION, OVERDOSAGE, HOW SUPPLIED - MedlinePlus Furosemide
Set id: n/a · Label effective or revised date: Last Revised - 04/15/2025 · Fetched at: 2026-11-02 · Sections used: all patient sections - openFDA drug label API (class)
Set id: n/a · Label effective or revised date: API last_updated 2026-10-30 · Fetched at: 2026-11-02 · Sections used: pharm_class_epc - Drugs@FDA
Label effective or revised date: NOT FOUND (not searched) · Fetched at: 2026-11-02 · Sections used: none
Information is taken from the cited sources and is for general reference only. It is not medical advice. Report side effects to FDA MedWatch at 1-800-FDA-1088. For a poison emergency call 1-800-222-1222. See prices for this drug