Entresto costs $550–$620 per month at list price without insurance. For patients who take it long-term, that cost adds up fast. Several programs can significantly reduce what you pay — and some patients qualify for free medication based on income.
This guide covers current Entresto pricing, all available savings programs, and every option for paying less in 2026. Check current Entresto prices at pharmacies near you on RxDiff before filling.
Entresto costs approximately $550–$620 per month at list price for a 30-day supply without insurance. Prices vary by pharmacy, dosage, and applicable savings programs. Most commercial insurance plans cover Entresto for approved indications with prior authorization. Medicare Part D also covers it, with the $2,000 annual out-of-pocket cap from the Inflation Reduction Act providing real protection for Medicare patients.
Entresto (sacubitril/valsartan) is approved for heart failure with reduced ejection fraction (HFrEF) and heart failure with preserved ejection fraction (HFpEF) in adults. It is manufactured by Novartis. Without insurance or a savings program, patients pay close to the list price — which is why the programs below matter significantly for anyone who relies on this medication long-term.
No generic sacubitril/valsartan is currently available in the United States. Entresto remains brand-only, making the Novartis savings programs below the primary cost-reduction tools for commercially insured and uninsured patients alike.
Entresto retail pricing is similar across major pharmacy chains — CVS, Walgreens, and Rite Aid all list it near the $550–$620 range without insurance or a savings card. The Novartis savings card is the most effective way to reduce cost for commercially insured patients.
For uninsured patients, independent pharmacy pricing may differ slightly. Use RxDiff to compare Entresto prices at pharmacies near you and identify any pricing differences before filling.
Discuss therapeutic alternatives with your cardiologist before switching — heart failure medications are highly individualized. Other medications used in heart failure management include ACE inhibitors and ARBs, which have generic versions available at much lower cost. However, Entresto's dual mechanism as an ARNI (angiotensin receptor-neprilysin inhibitor) is distinct from these alternatives. Do not switch without consulting your healthcare provider.
NeedyMeds.org and RxAssist.org are free directories for finding drug-specific patient assistance programs from manufacturers and non-profits. State pharmaceutical assistance programs may also be available for residents who don't qualify for Medicaid but struggle with high drug costs.
Most commercial insurance plans cover Entresto for approved indications with prior authorization required. Medicare Part D covers Entresto as a specialty medication with coinsurance after the deductible. The Inflation Reduction Act's $2,000 annual out-of-pocket cap provides meaningful protection for Medicare patients on high-cost drugs like Entresto. Check your specific formulary for current tier placement and copay amounts.
Prior authorization for Entresto requires your prescriber to document medical necessity before your insurance approves coverage. This typically takes 3–14 business days. If your insurer denies coverage, you have the right to appeal. Your prescriber can submit a letter of medical necessity supporting the appeal. Your pharmacist can also help initiate the prior authorization process.
Novartis offers a co-pay savings card for commercially insured Entresto patients that can reduce monthly out-of-pocket costs significantly. Eligibility requirements apply — Medicare and Medicaid patients are generally not eligible for manufacturer co-pay cards due to federal regulations. Drug manufacturer coupons like the Novartis savings card are the primary cost-reduction tool for commercially insured Entresto patients. Ask your pharmacist or healthcare provider for enrollment details at your next visit. The savings card application is typically available on the manufacturer's website or through your prescriber's office.
For uninsured patients who meet income eligibility requirements, the Novartis patient assistance program may provide Entresto at no cost. Income thresholds vary — apply directly through the manufacturer's website or ask your prescriber to connect you with their patient assistance navigator.
Compare Entresto prices at every pharmacy near you — free on RxDiff.
Find the Lowest Entresto Price on RxDiff →Cash prices vary by dose, quantity, pharmacy, and location. A current estimate is often several hundred dollars per month, so compare the exact prescription and ask about assistance.
The manufacturer may offer savings support for eligible patients. Check the current program rules and ask your prescriber or pharmacist for help applying.
Only a clinician should decide whether a different heart-failure treatment is appropriate. Do not stop Entresto without medical advice.
For authoritative information, see the FDA Drugs@FDA database. The FDA Drugs@FDA database contains official Entresto (sacubitril/valsartan) approval information and prescribing label.
Medical Disclaimer: This content is for informational purposes only. Drug prices change frequently — always verify current pricing at your pharmacy before filling. Consult your healthcare provider or pharmacist about your specific medications.