For 42 Xifaxan 550 mg tablets, this page's September 26, 2026 Reno RxGo discount-listing sample ranges from $2,824.74 to $2,910.57. These are dated local quotes for 42 tablets, not a guaranteed price for every fill; the separate comparison below uses only six tablets. Check the exact prescribed quantity on the RxDiff Xifaxan page and confirm the final price with the pharmacy.
Xifaxan, 42 x 550 mg tablets (30-day supply), Reno, NV 89501, as of September 26, 2026: Walgreens Specialty $2,824.74; Cancer Care Specialists $2,903.07; Raley's $2,910.57. Source: RxGo pricing data. Prices are estimates and vary by pharmacy, ZIP code and day. See current prices on the Xifaxan page.
| Source | Lowest price shown | Pharmacy |
|---|---|---|
| RxDiff (RxGo pricing data) — Lowest named pharmacy | $410.82 | Walgreens Specialty |
| SingleCare — Lowest price shown | $386.28 | Smiths |
Compared: Xifaxan 550 mg x 6 tablets.
We compared the same drug, strength, quantity and ZIP code on each source on September 26, 2026. We did not compare GoodRx. RxGo may list additional pharmacies without names. Prices are estimates, vary by pharmacy, ZIP and day, and either source can be lower on a given day. See current prices on the RxDiff drug page.
Xifaxan contains rifaximin and is a prescription tablet. What someone pays without insurance depends on strength, quantity, pharmacy, ZIP code, and current coverage or program terms. The snapshot above is a dated example, not a guaranteed quote.
Match the prescribed strength and quantity before comparing. Ask the pharmacist to confirm the product, stock, final amount, and whether a payment option applies. If cost is a barrier, ask the prescriber or pharmacist about safe next steps rather than substituting another antibiotic.
A plan copay, cash price, and discount-card listing can differ for the same prescription. Pharmacy benefit managers (PBMs) negotiate formulary terms and manufacturer rebates, but those rebates may not lower what someone pays at pickup. Deductibles, network rules, and prior authorization can also change the amount due.
Pharmacies set different markups and may have different purchasing terms or stock. Quotes can change by ZIP code and date, and a six-tablet comparison is not the price of the 42-tablet snapshot. Ask for the exact prescribed strength and quantity before comparing totals.
The FDA approved a generic rifaximin 550 mg tablet referencing Xifaxan in 2026, but approval does not guarantee local availability or a lower pharmacy price. Brand and generic coverage may differ by plan. Ask the pharmacist whether the approved generic can actually be obtained for your prescription before relying on it as a savings option.
Prices vary by pharmacy and can change. Compare a current quote for your exact prescription on the RxDiff Xifaxan page.
Ask your pharmacist to confirm the current quote and applicable terms for your prescription.
The price for a prescription can vary by pharmacy and prescription details. Ask your pharmacist to confirm the current quote before filling it.
Yes, at the approval level: the FDA approved a therapeutically equivalent rifaximin 550 mg generic referencing Xifaxan in March 2026. Approval is not the same as a guaranteed stocked, lower-priced option at every pharmacy, and availability may change. Ask the pharmacist whether it can fill the same prescribed strength and quantity with the generic and what the current price would be. Do not substitute a different antibiotic or change the prescribed course based only on a price page.
Compare discount cards. Request a card price for the exact 550 mg tablet count and ask whether the pharmacy accepts it. Compare the confirmed total with a cash or insurance quote; offers may not combine.
Check manufacturer support. Ask the brand program operator about current copay support or patient assistance for your circumstances. Verify insurance and income rules, covered product, and application steps before depending on an offer.
Shop pharmacies for the same quantity. Compare current quotes for the exact prescription, not the six-tablet comparison against a 42-tablet course. Ask whether an approved generic is in stock and what it would cost if your prescription permits it.
Ask about specialty channels if required. If a plan directs you to a preferred or specialty pharmacy, ask whether other participating pharmacies can fill the same prescription. Check delivery charges, availability, and the final amount before transferring it.
Appeal a coverage denial. If prior authorization is denied, request the plan's written reason and appeal process. Ask your prescriber about documentation or an exception request when appropriate; approval and timing are not guaranteed.
Program availability, eligibility, and terms can change. Check current program terms directly with the provider and ask your plan or pharmacist whether they apply to you.
Coverage and review processes vary by plan. Contact your insurer for current coverage information and ask your prescriber or pharmacist what information may be useful for your situation.
Compare a current quote on the RxDiff Xifaxan page. Ask your pharmacist or program provider about current discount and assistance terms before relying on them.
Ask the program provider whether assistance is currently available and whether its terms apply to you. See our general guide to patient assistance programs.
Check a current price for your prescription.
Compare Xifaxan prices on RxDiff →Prices vary by pharmacy and prescription. Compare a current quote on the RxDiff Xifaxan page and ask your pharmacist about applicable terms.
Program availability, eligibility, and terms can change. Check current terms with the program provider and ask your plan or pharmacist whether they apply to you.
Compare a current quote on the RxDiff Xifaxan page. Ask your pharmacist or program provider about current discount and assistance terms before relying on them.
Ask the program provider whether assistance is currently available and whether its terms apply to you. Your pharmacist or prescriber can help you identify questions to ask.
For the 550 mg generic approval, see the FDA rifaximin approval letter.
For product information, see the DailyMed Xifaxan (rifaximin) tablet label. You can also use the existing FDA drug database; verify the specific product information with your pharmacist.
Medical Disclaimer: This content is for informational purposes only and does not constitute medical or financial advice. Prices vary by pharmacy; check a current quote for your prescription. Consult your healthcare provider or pharmacist about your medications and treatment plan.
Editorial disclosure: RxDiff Editorial Team guides are for prescription price and savings information. They are not medical advice. Verify current prices, eligibility, and health information with the pharmacy, prescriber, pharmacist, or official source.